Sökning: "PLGA"
Visar resultat 1 - 5 av 15 avhandlingar innehållade ordet PLGA.
1. Poly(Lactide-co-Glycolide) in Controlled-Release Pharmaceuticals - Release Mechanisms
Sammanfattning : Controlled-release formulations reduce the frequency of injections and better maintain plasma concentrations within the therapeutic window. Poly(D,L-lactide-co-glycolide) (PLG) is currently the most frequently used biodegradable polymer for this application. LÄS MER
2. Nanoparticle-based drug delivery systems for neural interfaces - a novel approach for improved biocompatibility
Sammanfattning : The overall purpose of this thesis was to reduce brain tissue responses around implanted microelectrodes using a pharmacological strategy. One of the main aims was to develop and evaluate drug delivery systems that allow local administration of anti-inflammatory pharmaceutics. LÄS MER
3. Covalent Surface Modification of Degradable Polymers for Increased Biocompatibility
Sammanfattning : Degradable polymers have gained an increased attention in the field of biomedical applications over the past decades, for example in tissue engineering. One way of improving the biocompatibility of these polymers is by chemical surface modification, however the risk of degradation during the modification procedure is a limiting factor. LÄS MER
4. Synthesis of Polymeric Nanocomposites for Drug Delivery and Bioimaging
Sammanfattning : Nanomaterials have gained great attention for biomedical applications due to their extraordinary physico-chemical and biological properties. The current dissertation presents the design and development of multifunctional nanoparticles for molecular imaging and controlled drug delivery applications which include biodegradable polymeric nanoparticles, superparamagnetic iron oxide nanoparticles (SPION)/polymeric nanocomposite for magnetic resonance imaging (MRI) and drug delivery, manganese-doped zinc sulfide (Mn:ZnS) quantum dots (QDs)/ SPION/ polymeric nanocomposites for fluorescence imaging, MRI and drug delivery. LÄS MER
5. Synthesis and Characterization of Self-Assembling Low Molecular Weight Copolymers for Bioengineering Applications
Sammanfattning : The constant need for improved biomedical materials and the interest in producing materials with similar properties to the extracellular matrix in different tissues has resulted in increasing interest in research on hydrogels. Over the last decade self-assembling copolymers have been of particular interest since they form hydrogels in response to external stimuli such as temperature. LÄS MER