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Visar resultat 1 - 5 av 7 avhandlingar som matchar ovanstående sökkriterier.
1. Studies of PLAG1 and HMGIC fusion oncogenes in human tumors
Sammanfattning : .... LÄS MER
2. Studies of Fusion Oncogenes and Genomic Imbalances in Human Tumors
Sammanfattning : Cancer is a genetic disease caused by mutations and chromosome rearrangements affecting oncogenes and tumor suppressor genes in particular. Molecular analyses of recurrent translocations in hematological disorders, as well as in certain solid tumor types, have shown that they frequently result in fusion oncogenes. LÄS MER
3. Transcriptomic and functional studies of fusion oncogene-driven salivary gland tumors
Sammanfattning : Fusion genes are potent oncogenic drivers resulting from exchange of regulatory/coding sequences between two genes. They were originally identified in leukemias but are now recognized as key oncogenic events also in many solid tumors, including salivary gland tumors (SGTs). LÄS MER
4. Epigenetic mechanisms and regulatory aspects of human cancer and neural progenitor cells : implications for diagnosis and therapy
Sammanfattning : Epigenetic is defined as heritable modification or properties of the functional genome that are not directly embedded in the DNA sequence. Epigenetic changes include DNA methylation, histone modifications and RNA-mediated gene silencing. LÄS MER
5. Bioinformatic screening for candidate mutations underlying phenotypic traits in domestic animals
Sammanfattning : Domestic animals represent excellent model organisms for gene mapping and identification of mutations underlying phenotypic traits. Humans have selected spontaneous mutations in farm and companion animals since they were domesticated and this has resulted in large phenotypic variation among different breeds. LÄS MER