Sökning: "PIA rat model"

Visar resultat 1 - 5 av 12 avhandlingar innehållade orden PIA rat model.

1. 1. Natural Products as Leads for Pharmaceutically Active Compounds

   Författare :Pia Kahnberg; Centrum för analys och syntes; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; scaffold hopping; Catalyst; anxiety; benzodiazepine site; GABAA receptor; pharmacophore model; flavones; SAR; antifungal activity; Complex I; pterulone; Organic chemistry; Organisk kemi; Biochemical technology; Biokemisk teknik;

   Sammanfattning : In the search for new pharmaceutically active compounds, it is recognized that Nature produces structurally different compounds in a great variety. By having the compounds or extracts tested in defined systems, new drugs or more often leads (a compound that has an interesting but moderate activity) can be found. LÄS MER

3. 2. FROM DISEASE TO THE GENE - Identification of arthritis-regulating loci in rats

   Författare :Carola Rintisch; Immunologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pristane-induced arthritis; Rat strain; Autoimmunity; Rheumatoid arthritis; Quantitative trait locus;

   Sammanfattning : Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the peripheral joints that eventually leads to cartilage destruction and bone erosion. The causes of RA remain largely unknown, but considerable evidence suggests a multifactorial aetiology involving both environmental and genetic factors. LÄS MER

4. 3. Genetic Factors and Nasal Tolerance in Rat Models for Rheumatoid Arthritis

   Författare :Shemin Lu; Immunologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nasal tolerance; linkage analysis; MHC; genetics; pristane induced arthritis; rheumatoid arthritis; collagen induced arthritis; Immunology; serology; transplantation; Immunologi; serologi;

   Sammanfattning : We used three animal models of rats for rheumatoid arthritis (RA) in this study. Firstly, We found that CXI induced arthritis (CXIIA) is associated with the RT1 f haplotype and follows a chronic disease course affecting peripheral joints with both progression and relapses. LÄS MER

5. 4. Functional and genetic analyses of the MHC and its impact on autoimmunity in the rat

   Författare :Jonatan Tuncel; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The major histocompatibility complex (MHC) is an allele-rich and exceptionally gene dense region on human chromosome 6. Over 40% of the genes in this region have immune-related functions, including genes encoding MHCI and MHCII molecules. These molecules, which are found in nearly all vertebrates, present antigenic peptides to CD4 and CD8 T cells. LÄS MER

7. 5. New models for relapsing polychondritis and rheumatoid arthritis : focus on the tissue specific immune response

   Författare :Ann-Sofie Hansson; Immunologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; relapsing polychondritis rheumatoid arthritis matrilin-1 collagen model; Clinical biology; Klinisk biologi;

   Sammanfattning : Relapsing polychondritis (RP) and rheumatoid arthritis (RA) are autoimmune diseases where an inappropriate immune response destroys cartilage. In RP, the ears, larynx, nose and joints are affected, while the most prominent sign of RA is arthritis. LÄS MER