Sökning: "PI3K"

Visar resultat 21 - 25 av 155 avhandlingar innehållade ordet PI3K.

  1. 21. Genetic and Epigenetic Characterisation of Breast Tumours

    Författare :Karolina Holm; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; PIK3CA; PTEN; PI3K pathway; CCND1; microarrays; molecular subtypes; DNA methylation; EZH2; H3K27me3; PRC2; histone modification;

    Sammanfattning : Breast tumours harbour a large amount of genetic and epigenetic alterations, which are associated with e.g. tumour aggressiveness, prognosis, and response to therapy. LÄS MER

  3. 22. Erythropoietin receptor in growth control and anti-estrogen resistance of estrogen receptor positive breast cancer

    Författare :Susann Reinbothe; Avdelningen för translationell cancerforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tamoxifen resistance; proliferation; PI3k pathway; Breast cancer; erythropoietin receptor; estrogen receptor;

    Sammanfattning : The main function of Erythropoietin (EPO) and its receptor (EPOR) is the stimulation of erythropoiesis. Therefore, recombinant human EPO (rhEPO) is used to treat anemia in cancer patients, but some studies have reported that rhEPO treatment might promote tumor progression. Additionally, EPOR expression has been detected in various cancer forms. LÄS MER

  4. 23. Impact of Interleukin-6 family cytokine signalling on human endothelial cells and platelets

    Författare :Madelene Lindkvist; Magnus Grenegård; Liza Ljungberg; Alistair W. Poole; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; gp130 signalling cytokines; inflammation; transsignalling; JAK STAT; MEK ERK; PI3K AKT; platelet aggregation; vasodilation;

    Sammanfattning : Endothelial cells lining the luminal side of blood vessels creates a barrier between the circulating blood and the extracellular matrix. Endothelial cells have important functions in regulation of vessel tension and inflammation. LÄS MER

  5. 24. Alterations in the PI3K/AKT Signaling Pathway and Response to Adjuvant Treatment in Breast Cancer

    Författare :Gizeh Pérez-Tenorio; Olle Stål; Anne Lykkesfeldt; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Onkologi;

    Sammanfattning : (PI3K)/AKT signaling pathway could be a cause of therapeutic resistance in breast cancer. The PI3K/AKT pathway controls cell proliferation, cell growth and survival, and its members include oncogenes and tumor suppressor genes. Alterations in this pathway are frequent in cancer. LÄS MER

  7. 25. Molecular mechanisms of ovarian follicular development and early embryogenesis

    Författare :Nagaraju Gorre; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ovary; primordial follicles; Embryogenesis; PI3K-mTORC1 signaling;

    Sammanfattning : In the mammalian ovary, the dormant primordial follicles are the source of developing follicles and fertilizable ova for the entire reproductive life. In addition, the duration of fertility of a female is determined by the initial size of her pool of primordial follicles and by the rate of its activation and depletion. LÄS MER