Sökning: "PI3K"

Visar resultat 11 - 15 av 155 avhandlingar innehållade ordet PI3K.

  1. 11. Signal Transduction in Malignant Cells – Transformation, Activation and Differentiation

    Författare :Karin Kårehed; Fredrik Öberg; Jan-Ingvar Jönsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Molecular medicine; transformation; PDGF; PI3K; Rho-GTPase; U-937; FcγRI; macrophage; Stat1; PKR; NFκB; ATRA; differentiation; Molekylärmedicin; Molecular medicine genetics and pathology ; Molekylär medicin genetik och patologi ; Pathology; Patologi;

    Sammanfattning : All aspects of cell life are regulated by signal transduction mechanisms. This thesis describes the regulatory roles of a few key signal transduction molecules involved in three major biological responses. LÄS MER

  3. 12. Structural and Functional Aspects of β1 Integrin Signalling

    Författare :Stina Nilsson; Staffan Johansson; Teet Velling; Maria Fällman; Uppsala universitet; []
    Nyckelord :Cell and molecular biology; Integrin; Integrin subunit β1; Integrin activation; Threonine; Phosphorylation; Integrin signalling; FAK; PI3K; MAPK; Cell- och molekylärbiologi;

    Sammanfattning : Integrins are transmembrane glycoproteins primarily mediating interactions of cells with the extracellular matrix. Each receptor is a complex of one α- and one β-subunit with affinity for a diverse set of ligands. LÄS MER

  4. 13. Signaling pathways in the development of female germ cells

    Författare :Deepak Adhikari; Kui Liu; Elisabet Stener-Victorin; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ovary; primordial follicle; activation; mTORC₁; PI₃K; oocyte maturation; MPF; Cdk₁; medicinsk biokemi; Medical Biochemistry;

    Sammanfattning : Primordial follicles are the first small follicles to appear in the mammalian ovary. Women are born with a fixed number of primordial follicles in the ovaries. Once formed, the pool of primordial follicles serves as a source of developing follicles and oocytes. LÄS MER

  5. 14. Regulation of survival and proliferation of human intestinal epithelial cells by leukotriene D4

    Författare :Sailaja Paruchuri; Malmö Experimentell patologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rac; General pathology; pathological anatomy; Patologi allmän ; patologisk anatomi; PI3K; CREB; p90RSK; Erk-1 2; PKC; inflammation; migration apoptosis; proliferation; LTD4; cell survival;

    Sammanfattning : The pro-inflammatory mediator, Leukotriene D4 (LTD4) is a product of arachidonic acid cascade and has been implicated in asthma and inflammatory bowel diseases. Prolonged inflammatory conditions like ulcerative colitis increases the risk for the development of cancer and the factors that induce the chronic immune response remain uncertain. LÄS MER

  7. 15. Role of Cell-cell Interactions and Palmitate on β-cells Function

    Författare :Azazul Islam Chowdhury; Peter Bergsten; Gunilla Westermark; Peter Jones; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Metabolism; PI3K; Pseudoislets; Human islets; SOCS; PIAS; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

    Sammanfattning : The islets of Langerhans secrets insulin in response to fluctuations of blood glucose level and efficient secretion requires extensive intra-islet communication. Secretory failure from islets is one of the hallmark in progression of type 2 diabetes. LÄS MER