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Visar resultat 1 - 5 av 155 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Integrin Signaling in Cell Adhesion and Mechanotransduction : Regulation of PI3K, AKT, and ROS

    Författare :Kathrin Stephanie Zeller; Staffan Johansson; Kristofer Rubin; John Couchman; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; integrin; ROS; PI3K; AKT; mechanosignaling; actin polymerization; spreading;

    Sammanfattning : Integrins are a family of conserved cell surface receptors found throughout the animal kingdom. They comprise 24 dimers in mammals, and regulate a number of processes including cell survival, differentiation, and migration. LÄS MER

  3. 2. From 1p3 to PI3K - Studies of neuroblastoma

    Författare :Susanne Fransson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; neuroblastoma; PI3K; PIK3CD; 1p36; alternative splicing; tumor; neural crest; mucosa; premalignant; tumor suppressor gene; oncogene; gene expression; epigenetics; splicing; signaling; akt; western blot; TaqMan; PIK3R1; p110H; p37H; p85; RAS;

    Sammanfattning : Neuroblastoma (NB) is a tumor of the sympathetic nervous system and is the most common extra-cranial tumor of childhood, accounting for 7% of all pediatric malignancies. Despite recent advances in therapeutics, outcome is still fatal for patients with aggressive NB and side-effects of treatment are severe. LÄS MER

  4. 3. IGF, PI3K and HIF-2 in Normal and Tumor Development

    Författare :Sofie Mohlin; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuroblastoma; Hypoxia; Insulin-like Growth Factor; PI3K; HIF-2alpha; Cancer; Development;

    Sammanfattning : Cells adapt to oxygen shortage, hypoxia, by inducing a transcriptional shift governed mainly by Hypoxia Inducible Factor (HIF)-1 and HIF-2. In various cancer forms, including neuroblastoma, high expression of HIF-2α correlates with disseminated disease and poor outcome. LÄS MER

  5. 4. Molecular studies of intra-oocyte phosphatidylinositol 3 kinase (PI3K) signaling pathway in controlling female fertility

    Författare :Pradeep Reddy Dubbaka Venu; Kui Liu; Evelyn Telfer; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Primordial follicles; Oocyte; PI3K; Biochemistry; Biokemi; Developmental Biology; miljömedicinsk utvecklingsbiologi;

    Sammanfattning : The primordial follicle pool is the main source of developing follicles in the ovary. The length of reproductive life and the onset of menopause are governed by the amount of primordial follicles in the ovary. LÄS MER

  7. 5. Molecular mechanisms for activation of non-canonical TGFβ pathways and their importance during prostate cancer progression

    Författare :Anahita Hamidi; Marene Landstöm; Carl-Henrik Heldin; Ramin Massoumi; Uppsala universitet; []
    Nyckelord :TGFβ; AKT; PI3K; p85α; TRAF6; TAK1; NF-κB; Src; prostate cancer; PC-3U; cell migration; inflammation; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

    Sammanfattning : Prostate cancer is the most common invasive cancer diagnosed in men and a major and growing health problem in Western countries. Deregulation of different pathways has been implicated in progression of prostate cancer, namely nuclear factor kappa enhancer binding protein (NF-κB), transforming growth factor β (TGFβ), phosphoinositide 3ʹ-kinase/AKT (PI3K/AKT) and Src kinase pathways. LÄS MER