Sökning: "PHARMACY Pharmaceutical pharmacology"
Visar resultat 1 - 5 av 46 avhandlingar innehållade orden PHARMACY Pharmaceutical pharmacology.
1. Solid state characterisation and compaction behaviour of pharmaceutical materials
Sammanfattning : In this thesis, factors important in tableting operations and for tablet properties have been studied and characterised by different spectroscopic techniques as well as by some more conventionally used particle characterisation techniques. The spectroscopic techniques solid-state NMR, FT-IR and NIR spectroscopy, proved to be valuable tools in the estimation of particle and tablet properties, offering both specificity and sensitivity in the measurements. LÄS MER
2. Pharmaceutical binders and their function in directly compressed tablets : Mechanistic studies on the effect of dry binders on mechanical strength, pore structure and disintegration of tablets
Sammanfattning : In this thesis, the strength-enhancing mechanisms of dry binders in direct compression were studied. The systems investigated were binary mixtures containing various compounds and binders. Among the binders used were a series of different molecular weights of polyethylene glycol. LÄS MER
3. A supercritical fluids extraction process for the production of drug loaded biodegradable microparticles
Sammanfattning : The purpose of this thesis was to develop methods suitable for the incorporation of drug substancessuch as proteins into microparticles intended for controlled release. In particular a novel techniquefor the preparation of microparticles using supercritical fluids was investigated. LÄS MER
4. Modelling and prediction of drug transport processes with experimental and calculated molecular properties : A multivariate approach
Sammanfattning : Less than 2% of the lead compounds generated by the pharmaceutical industry enter the exploratory drug-development phase, from which point they stand only a 10% chance of becoming a commercial medicine. A large proportion of the compounds fail due to poor biopharmaceutical properties, such as permeability and solubility. LÄS MER
5. Nasal administration of compounds active in the central nervous system : Exploring the olfactory system
Sammanfattning : The nasal administration of drugs offers advantages over administration by intravenous injection. Drugs can be rapidly absorbed through the nasal mucosa, resulting in a rapid onset of action, and also avoiding degradation in the gastrointestinal tract and first-pass metabolism in the liver. LÄS MER
