Sökning: "PHARMACY Biopharmacy"

Visar resultat 21 - 25 av 49 avhandlingar innehållade orden PHARMACY Biopharmacy.

  1. 21. The Role of the Melanocortin System in Linking Energy Homeostasis with Reward Mechanisms

    Författare :Jonas Lindblom; Per Södersten; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; farmaceutisk farmakologi; Pharmaceutical Pharmacology;

    Sammanfattning : There is evidence of a link between peripheral signals of energy homeostasis and reward mechanisms. A hypothesis was formulated that the melanocortin (MC) system is part of this link. The hypothesis was tested by a series of receptor expression and neurochemical studies in rats. LÄS MER

  3. 22. Validation of Several Nucleoside Tracers as Proliferation Markers

    Författare :Li Lu; Sven Reske; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biopharmacy; PET; cell proliferation; DNA synthesis; hydroxyurea; cimetidine; diuretic; Biofarmaci; Biopharmacy; Biofarmaci; galenisk farmaci; Pharmaceutics;

    Sammanfattning : Positron emission tomography (PET) is a powerful method for in vivo characterization of tumor biochemistry and clinically has been used for diagnosing and grading of malignancy. A key element in oncology is proliferation potential, a feature that is assumed to be an important indicator of tumor growth. LÄS MER

  4. 23. Melanogenesis as the basis for melanoma targeting

    Författare :Ulla Mårs; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; Toxicology; toxikologi;

    Sammanfattning : The incidence of malignant melanoma has increased rapidly during the last decades, and the prognosis for disseminated melanoma is poor. The melanoma cells produce melanin, and therefore the melanogenesis may serve as a target for treatment of melanotic melanoma; thioureyelenes such as thiourea and 2-thiouracil, e.g. LÄS MER

  5. 24. Cytochrome P450 Enzymes in the Metabolism of Cholesterol and Cholesterol Derivatives

    Författare :Maria Norlin; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; farmaceutisk biokemi; Pharmaceutical Biochemistry;

    Sammanfattning : Cholesterol is metabolized to a variety of important biological products in the body including bile acids and vitamin D. The present investigation is focused on enzymes that catalyze 7α-hydroxylation or 27-hydroxylation in the metabolism of cholesterol, oxysterols (side chain-hydroxylated derivatives of cholesterol) and vitamin D3. LÄS MER

  7. 25. Involvement of the Opioid System in High Alcohol Consumption : Environmental and Genetic Influences

    Författare :Karolina Ploj; Jörgen A Engel; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Opioids; ethanol; stress; maternal separation; neonatal handling; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; farmaceutisk farmakologi; Pharmaceutical Pharmacology;

    Sammanfattning : It is well accepted that both inherent and environmental factors influence the pathogenesis of alcohol dependence. This thesis investigates the role of the opioid system in the initiation and maintenance of high ethanol intake. LÄS MER