Sökning: "PHARMACY Biological research on drug dependence"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden PHARMACY Biological research on drug dependence.

  1. 1. The Impact of Nandrolone Decanoate on Neuropeptidergic Mechanisms Related to Cognition, Aggression, Reward and Dependence

    Författare :Kristina Magnusson; Fred Nyberg; Mathias Hallberg; Santi Mario Spampinato; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anabolic androgenic steroids; Nandrolone decanoate; Substance P; Dynorphin A; KOP receptor; Prodynorphin; Radioimmunoassay; Autoradiography; Morris water maze; PCR; Central nervous system; Biological research on drug dependence; Biologisk beroendeforskning; Biological Research on Drug Dependence; Biologisk beroendeforskning;

    Sammanfattning : The abuse of anabolic androgenic steroids (AAS) is becoming increasingly common and may result in a range of physiological as well as psychological effects such as altered behavior in terms of increased aggression, cognitive dysfunction and addictive behavior. AAS comprise testosterone and its derivatives, of which nandrolone is one of the more common. LÄS MER

  3. 2. Levodopa- and Neuroleptic-Induced Dyskinesias : Studies on Pharmacological Modification and Processing of Opioid Neuropeptides

    Författare :Rebecka Klintenberg; Alan Crossman; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biological research on drug dependence; Opioid peptides; dyskinesia; Parkinson s disease; mass spectrometry; metabolism; Biologisk beroendeforskning; Biological research on drug dependence; Biologisk beroendeforskning; biologisk beroendeforskning; Biological Research on Drug Dependence;

    Sammanfattning : Dyskinesias or abnormal involuntary movements are a debilitating complication of long-term levodopa treatment of Parkinson’s disease (PD) that is widely experienced and may compromise the efficacy of the drug therapy. Tardive dyskinesia is another important adverse effect seen with antipsychotic drug treatment. LÄS MER

  4. 3. Growth Hormone and Anabolic Androgenic Steroids : Effects on Neurochemistry and Cognition

    Författare :Alfhild Grönbladh; Mathias Hallberg; Jörgen Isgaard; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Growth hormone; anabolic androgenic steroids; nandrolone decanoate; insulin-like growth factor; GABAB; opioids; memory; water maze; autoradiography; central nervous system; rats; Biological Research on Drug Dependence; Biologisk beroendeforskning;

    Sammanfattning : Growth hormone (GH) stimulates growth and metabolism but also displays profound effects on the central nervous system (CNS). GH affects neurogenesis and neuroprotection, and has been shown to counteract drug-induced apoptosis in the brain. LÄS MER

  5. 4. Anabolic Androgenic Steroids and the Brain : Studies of Neurochemical and Behavioural Changes Using an Animal Model

    Författare :Pia Steensland; Christina Gianoulakis; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Anabolic Androgenic Steroids AAS ; aggression; alcohol intake; defensive behaviours; dependence; opioid peptides; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; biologisk beroendeforskning; Biological Research on Drug Dependence;

    Sammanfattning : A new group of anabolic androgenic steroid (AAS) users has developed during the last two decades. This group consists primarily of young men interested in improving their physical appearance. Within this group, AAS are sometimes used together with other illicit drugs, alcohol and nicotine. LÄS MER

  7. 5. Anabolic Androgenic Steroids : Effects on Neuropeptide Systems in the Rat Brain

    Författare :Mathias Hallberg; Fred Nyberg; Pierre Le Grevès; James Zadina; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biological research on drug dependence; Anabolic androgenic steroids; Nandrolone decanoate; Substance P; NK1 receptor; Substance P 1-7 ; Endopeptidase; Opioids; Calcitonin gene-related peptide; Radioimmunoassay; Autoradiography; Central nervous system; Rats; Biologisk beroendeforskning; Biological research on drug dependence; Biologisk beroendeforskning;

    Sammanfattning : Anabolic-androgenic steroids (AAS) have been used in clinics for decades. The misuse of AAS has previously been attributed merely to sport athletes, taking AAS with intentions to increase muscle mass, enhance physical performance and to improve results in competitions. LÄS MER