Sökning: "PGM"

Visar resultat 1 - 5 av 13 avhandlingar innehållade ordet PGM.

  1. 1. Effect of hydration on thermodynamic, rheological and structural properties of mucin

    Författare :Yana Znamenskaya; Malmö högskola; []
    Nyckelord :mucous gel; mucus; mucin; PGM; BSM; BSM chitosan multilayers; hydration; water sorption isotherm; relative humidity; water activity; bound water; enthalpy of hydration of biopolymer; glass transition; rheology; phase diagram; fiber-like structure; dumbbell-like structure; sorption calorimetry; DSC; QCM-D; SAXS; AFM;

    Sammanfattning : Mucus, an adherent hydrated layer covering the epithelium, is found in all internal tracts of the body and plays an important role in animal and human life. One of the essential functions of mucus is protection of tissues against dehydration. LÄS MER

  3. 2. On the Development of Mucin-based Biomaterial Coatings

    Författare :Tomas Sandberg; Karin Caldwell; Jan Carlsson; Thomas Arnebrant; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mucin; Biomaterial; Surface-exposed protein; XPS; Neutrophil; Cell morphology; SEM; QCM-D; Viscoelasticity; Protein-stabilization; HNL; Coating; MG1; BSM; PGM; SEC-MALS-RI; Mucin quantification; Protein adsorption; Ellipsometry; Biomaterials; Biomaterial;

    Sammanfattning : Owing to their key role in mucosal functioning as surface barriers with biospecific interaction potentials, the mucins are interesting candidates for use as surface modifiers in biomaterials applications. In this work, “mild” fractionation procedures were used to prepare mucins of bovine (BSM), porcine (PGM), and human (MG1) origin. LÄS MER

  4. 3. Development of mathematical modelling for the glycosylation of IgG in CHO cell cultures

    Författare :Liang Zhang; Véronique Chotteau; Michael J. Betenbaugh; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Chinese hamster ovary cells; glycosylation; IgG; mathematical modelling; experimental design; perfusion; carbon sources; GReBA; Bayesian network; probabilistic graphic model; Bioteknologi; Biotechnology;

    Sammanfattning : Chinese hamster ovary (CHO) cells are the most popular expression system for the production of biopharmaceuticals. More than 80% of the approved monoclonal antibodies (mAbs) or immunoglobulin G (IgG) are produced with these cells. Glycosylation is a usual post- translational modification important for therapeutic mAbs. LÄS MER

  5. 4. A beta-phosphoglucomutase in carbohydrate metabolism of Lactococcus lactis

    Författare :Ny Qian; Teknisk mikrobiologi; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; mykologi; virologi; bakteriologi; Mikrobiologi; mycology; gene regulation; beta-phosphoglucomutase; maltose metabolism; lactate; metabolic engineering; alpha-phosphoglucomutase; Lactococcus lactis; Microbiology; virology; bacteriology; Biochemistry; Metabolism; Biokemi;

    Sammanfattning : Phosphoglucomutase (PGM) catalyzes the reversible conversion of glucose 1-phosphate to glucose 6-phosphate. Two distinct forms of PGM have been purifed and charactierized in Lactococcus lactis growing on maltose: one specific for the alpha-isomer, and the other specific for the beta-isomer of glucose 1-phosphate. LÄS MER

  7. 5. Beta-glucose 1-phosphate interconverting enzymes in Lactococcus lactis: physiological role and regulation in maltose, trehalose and glucose metabolism

    Författare :Ulrika Andersson; Teknisk mikrobiologi; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; virology; mycology; Mikrobiologi; bakteriologi; virologi; mykologi; Biochemical technology; Biokemisk teknik; bacteriology; Microbiology; Kemiteknik och kemisk teknologi; Chemical technology and engineering; trehalose 6-phosphate phosphorylase; beta-phosphoglucomutase; maltose phosphorylase; glucose; trehalose; maltose; Lactococcus lactis; beta-glucose 1-phosphate;

    Sammanfattning : Lactic acid bacteria (LAB), including Lactococcus lactis, are abundant in nature. These bacteria convert carbohydrates into mainly lactate by a rather uncomplicated metabolism. An improved understanding of the physiological and genetical mechanisms involved in carbohydrate metabolism and its regulation will improve the industrial use of LAB. LÄS MER