Sökning: "PET-ligand"
Hittade 4 avhandlingar innehållade ordet PET-ligand.
1. Characterization of Diagnostic Tools and Potential Treatments for Alzheimer’s Disease : PET ligands and BACE1 inhibitors
Sammanfattning : Alzheimer’s disease (AD) is a very complex disorder and the most common form of dementia. The two pathological hallmarks of AD are extracellular amyloid-β (Aβ) plaques in cerebral cortex, and intraneuronal neurofibrillary tangles. LÄS MER
2. Development of nicotinic receptor ligands for positron emission tomography - from in vitro to in vivo : Binding studies of neuronal nicotinic acetylcholine receptors using different ³H-, ¹1C- and `6Br - labeled ligands
Sammanfattning : Neuronal nicotinic acetylcholine receptors (nAChRs) are involved in central processes, such as cognitive functionand memory, and play a critical role in neuropathological changes in Alzheimer's disease (AD). The in vivocharacterization of nAChRs by positron emission tomography (PET) may increase our understanding of thefunctional implications of these receptors in AD and their early changes during this disease. LÄS MER
3. Markers of inflammation and neurodegeneration in muliple sclerosis
Sammanfattning : The main line of my thesis projects is searching for biomarkers and evidence of optimal correlation with clinical and para-clinical outcome measurements in multiple sclerosis (MS): investigating the biochemical biomarker in blood/plasma (cerebrosterol) and in cerebrospinal fluid (CSF) (oligoclonal bands (OCB)) and the correlation with MRI lesion load (paper 1 and paper IV); investigating the genetic biomarker (CYP46A1) for susceptibility and disability progression in MS (Paper III); comparison of the well-known positron emission tomography (PET) ligand and peripheral benzodiazepine receptor (PBR) antagonist, [11C]PK11195, and a new PET ligand [11C]vinpocetine (tissue receptor biomarker). Both ligands denote areas of active ongoing inflammation in MS (paper II). LÄS MER
4. Preclinical PET imaging and therapy of Alzheimer's disease
Sammanfattning : The main histopathological hallmarks of Alzheimer’s disease are extracellular amyloid-beta (Aβ) plaques and intracellular neurofibrillary tangles, containing tau protein. Because of misfolded and aggregated proteins, activated microglia and astroglia react with a neuroinflammatory response, which may contribute to disease progression and severity. LÄS MER