Sökning: "PDZK1"

Hittade 3 avhandlingar innehållade ordet PDZK1.

1. 1. Mucins, Cystic Fibrosis and PDZ protein interactions

   Författare :Emily Malmberg; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mucin; PDZ; transmembrane; MUC1; Cystic Fibrosis; clathrin; CFTR; PDZK1; Bcr; endocytosis; MUC17;

   Sammanfattning : Cystic Fibrosis (CF) is caused and characterized by mutations in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) gene. The dominating feature of the disease is mucus accumulation on mucosal surfaces, but no direct functional connection between mucus and CFTR is known. LÄS MER

3. 2. The Relationship between Transmembrane Mucins, Ion Channels and PDZ Adaptor Proteins in the Small Intestine

   Författare :Thaher Pelaseyed; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; intestine; mucin; MUC3; MUC17; SEA; PDZK1; GOPC; CFTR; NHE3;

   Sammanfattning : The human body is continuously exposed to challenges from the surrounding world. In analogy with the skin, mucus is a well-organized and highly regulated barrier composed of polymeric and O-glycosylated mucins that protects luminal organs such as the gastrointestinal tracts from the outer milieu. LÄS MER

4. 3. Autoantigens in Inflammatory Bowel Disease and Primary Sclerosing Cholangitis

   Författare :Brita Ardesjö; Olov Ekwall; Olle Kämpe; Fredrik Rorsman; Eric Gershwin; Uppsala universitet; []
   Nyckelord :Molecular medicine; inflammatory bowel disease; primary sclerosing cholangitis; autoimmunity; autoantigen; goblet cell; Molekylärmedicin;

   Sammanfattning : Inflammatory bowel disease (IBD) comprises diseases that are characterized by chronic or relapsing inflammation of the gastrointestinal tract. Primary sclerosing cholangitis (PSC) is an extraintestinal manifestation in IBD. LÄS MER