Sökning: "PDX model"
Visar resultat 1 - 5 av 11 avhandlingar innehållade orden PDX model.
1. Translational and clinical aspects of pancreatic cancer
Sammanfattning : Pancreatic cancer is a disease with dismal prognosis due to late detection and ineffective treatments. The majority of the patients already have disseminated disease at the time of diagnosis. The only potential curative treatment, surgery, is extensive with high morbidity and non-ignorable mortality. LÄS MER
2. Using genetics to identify epigenetic and signal transduction targets in cancer
Sammanfattning : Cancer arises mostly due to the stepwise acquisition of untamed growth capabilities by various means, ranging from genetic, epigenetic to environmental factors. With the advancement made in molecular biology and associated fields, the complex biological circuits leading to these pathological conditions have now started to be deciphered in-depth. LÄS MER
3. Novel immunotherapies for metastatic melanoma - from mouse models towards clinical trials
Sammanfattning : Immunotherapies including checkpoint blockade and adoptive T cell transfer (ACT) show great promise for the treatment of melanoma, with long-term effects in some patients. However, around half of the patients with metastatic malignant melanoma will not be cured with available therapies today, and these patients require other treatment strategies. LÄS MER
4. Translational studies of metastatic melanoma in the era of immunotherapy - from humanized mouse models to clinical trials
Sammanfattning : Immunotherapy with PD-1 inhibitors has transformed the treatment of met-astatic cutaneous mela- noma, and can lead to complete and durable responses in a proportion of patients. However, in around half of the patients, the treatment has little or no effect. LÄS MER
5. Hypoxia and Stem Cells in Normal and Tumor Development
Sammanfattning : Neuroblastoma is a childhood malignancy of the sympathetic nervous system and accounts for 15% of all cancer-related deaths in children. To understand the biology behind neuroblastoma, clarify timing of cellular events and expression profiles of proteins preceding neuroblastoma initiation, we need more relevant preclinical models. LÄS MER