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Visar resultat 1 - 5 av 19 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Studies on the Roles of PDGFRA and EGFR in the Classification and Identification of Therapeutic Targets for Human Gliomas

    Författare :Dongfeng Chen; Neurokirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gliomas; classification; EGFR; PDGFRA; FGF2; surface expression; cell proliferation;

    Sammanfattning : Glioma is the most common type of primary tumor in the adult central nervous system (CNS). However, the current classification of gliomas is highly subjective and even inaccurate in some cases, which leads to clinical confusion and hinders the development of targeted therapies. LÄS MER

  3. 2. Functional Studies on the PDGFR α gene promoter and effects of autocrine PDGF-A stimulation in vivo

    Författare :Xiao-Qun Zhang; Hubert Schorle; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Autorcrine PDGF; promoter; PDGFRA; transgenic mice; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Sammanfattning : Platelet-derived growth factor receptor α (PDGFRα) plays an important role during embryogenesis. After implantation, the patterns of expression of Pdgfrα and its ligand Pdgf-A undergo an "autocrine-paracrine transition", in that Pdgf-A becomes expressed in the ectoderm and epithelia, while Pdgfrα is expressed in the adjacent mesenchymal tissue. LÄS MER

  4. 3. Endosonography and pretreatment tumor profiling - from sampling, staining, to sequencing

    Författare :Per Hedenström; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; endosonography; fine-needle biopsy; pancreatic neoplasms; gastrointestinal stromal tumors; KIT; PDGFRA; Ki-67; imatinib; neoadjuvant therapy;

    Sammanfattning : Background and aims: Endosonography-guided fine needle aspiration (EUS-FNA) is imperfect in diagnosing solid pancreatic lesions (SPL) and subepithelial lesions (SEL) including gastrointestinal stromal tumors (GIST). In GISTs, imatinib therapy is effective only in variants of oncogenes KIT and PDGFRA. LÄS MER

  5. 4. Gastrointestinal stromal tumors. Pathogenetic mechanisms, phenotypic characterization and prognosis

    Författare :Johanna Andersson; Göteborgs universitet; []
    Nyckelord :Gastrointestinal stromal tumor GIST ; neurofibromatosis type I NF1 ; mutation; prognosis; denaturating high performance liquid chromatography dHPLC ; sequencing; KIT; PDGFRA; NF1;

    Sammanfattning : Gastrointestinal stromal tumor (GIST), the most common non-epithelial neoplasm of the gastrointestinal tract, has historically been problematic both conceptually and clinically. Recently, GIST has been shown to share phenotypic features with the interstitial cells of Cajal (ICC), including the almost uniform expression of the tyrosine kinase receptor KIT. LÄS MER

  7. 5. DNA repair by HDR in experimental tumorigenesis

    Författare :Ulrica Westermark; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The aim of this thesis was to further understand how defects in the homology-directed repair (HDR) pathway affect tumor formation and development. To study proteins involved in HDR is challenging since most of its members are required for cell viability. LÄS MER