Sökning: "PDGFR-β"

Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet PDGFR-β.

  1. 1. Fibroblast Growth Factor Receptor-1 Function in Vasculo- and Angiogenesis

    Författare :Peetra Magnusson; Lena Claesson-Welsh; Anne Eichmann; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pathology; FGF; FGFR-1; VEGFR-2; PDGFR-β; endothelial cells; embryonic stem cell; angiogenesis; hematopoiesis; Patologi; Pathology; Patologi;

    Sammanfattning : During development of the mammalian embryo, spatial and temporal expression of fibroblast growth factors (FGFs) and their cognate receptors are vital in the regulation of a number of patterning processes. Inappropriate or decreased expression leads to severe malformations and even embryonic death. LÄS MER

  3. 2. Hypoxia, PDGF and VEGF in Vascular Development

    Författare :Ingrid Nilsson; Lena Claesson-Welsh; Randall Johnson; Uppsala universitet; []
    Nyckelord :Cell biology; hypoxia; VEGF; VEGFR-3; PDGF; endothelial cell; embryonic stem cell; angiogenesis; lymphangiogenesis; Cellbiologi;

    Sammanfattning : The mechanisms behind many important aspects of blood- and lymphatic vessel formation have yet not been elucidated in detail. The primary objectives of this thesis have therefore been to study the effects of hypoxia, platelet-derived growth factor (PDGF) and vascular endothelial growth factors (VEGFs) on vascular development and function. LÄS MER

  4. 3. Modeling PDGF-driven gliomagenesis in the mouse

    Författare :Inga Nazarenko; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Gliomas are the most common form of brain tumors, with glioblastoma being the most aggressive form. Glioblastoma is characterized by a number of genetic aberrations, among them amplification and overexpression of platelet-derived growth factor receptor alpha (PDGFRA) that sometimes occurs together with inactivating mutations or loss of the tumor suppressor p53 (TP53). LÄS MER

  5. 4. Tumor microenvironment derived biomarkers in renal cell cancer

    Författare :Magnus Frödin-Bolling; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Renal cell carcinoma (RCC) is the 13th most common malignancy worldwide, and constitutes around 2% of all malignant tumors. The entity renal cell carcinoma comprises a heterogenous group of malignant tumors that originates from the epithelial cells in the renal proximal tubule. LÄS MER

  7. 5. Extracellular factors for preservation and delivery of stromal cells

    Författare :Kim Olesen; Karl-Henrik Grinnemo; Andreas Tilevik; Wing Cheung Mak; Cecilia Österholm; Magnus Fagerlind; Yuji Teramura; Högskolan i Skövde; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Infection Biology; Infektionsbiologi;

    Sammanfattning : Modulating the immune response after a myocardial infarction seems like an appropriate strategy for reducing myocardial fibrosis. Mesenchymal Stromal Cells are immunomodulatory and have thus gained interest, but have so far not achieved the desired clinical outcomes. LÄS MER