Sökning: "PDGF receptor"

Visar resultat 1 - 5 av 102 avhandlingar innehållade orden PDGF receptor.

  1. 1. Functions of PDGF-A and -C. Essential ligands for the PDGF alpha receptor

    Författare :Hans Boström; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; platelet-derived growth factor; PDGF-A; PDGF-C; PDGF alpha receptor; extracellular retention; gene targeting; mouse development; epithelial-mesenchymal interaction; lung; alveolar formation; spina bifida; gastrointestinal villus;

    Sammanfattning : Altered protein kinase activity is a contributing factor in many diseases including most formsof human malignancies, and there is reason to believe that protein kinases will prove to be majordrug targets in the treatment of cancer. Protein kinases mediate most of the signal transduction ineukaryotic cells, regulating cellular events such as transcription, metabolism, proliferation,cytoskeletal rearrangement, migration, differentiation and apoptosis. LÄS MER

  3. 2. Inhibition of PDGF receptor signaling in tumor stroma : Effects on interstitial hypertension, drug uptake and therapeutic response

    Författare :Kristian Pietras; Sven Påhlman; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; PDGF; tumor; stroma; tyrosine kinase inhibitor; combination therapy; Onkologi; Oncology; Onkologi; molekylär cellbiologi; Molecular Cellbiology;

    Sammanfattning : The role of platelet-derived growth factor (PDGF) in malignancies involves both autocrine and paracrine stimulation of cells within the tumor. The interstitial fluid pressure (IFP) is one of the forces that govern the transvascular flow of fluids. LÄS MER

  4. 3. Modulation of PDGF Receptor Signaling via the Phosphatase SHP-2 and the Docking Protein Gab1

    Författare :Anders Kallin; Lars Rönnstrand; Carl-Henrik Heldin; Per Lindahl; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; PDGF; SHP-2; Gab1; chemotaxis; actin reorganization; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi;

    Sammanfattning : x.... LÄS MER

  5. 4. Studies of PDGF receptor signaling in vitro and in vivo

    Författare :Maria Tsioumpekou; Carl-Henrik Heldin; Jean-Baptiste Demoulin; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PDGF; signaling; cancer; Erk5; kinase; Cbl; ubiquitination; deubiquitinase; pericytes; tumor growth; angiogenesis; low molecular weight inhibitors;

    Sammanfattning : Platelet-derived growth factor receptor (PDGFR) signaling is essential for proliferation, migration and survival of cells of mesenchymal origin; however, its deregulation has been associated with various diseases, including cancer. The aim of this thesis was to clarify the molecular mechanisms of PDGFR signaling regulation. LÄS MER

  7. 5. T-Cell Protein Tyrosine Phosphatase, a Regulator of the PDGF Signaling Pathway

    Författare :Susann Karlsson; Carina Hellberg; Carl-Henrik Heldin; Bengt Hallberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PDGF; TC-PTP; receptor trafficking; PK-M2; Medical cell biology; Medicinsk cellbiologi; molekylär cellbiologi; Molecular Cellbiology;

    Sammanfattning : Platelet-derived growth factor (PDGF) is a potent stimulator of cell growth, survival and motility. PDGF exerts its function by binding to specific tyrosine kinase receptors, initiating receptor auotphosphorylation and initiation of specific signaling pathways that regulates the cellular response. LÄS MER