Sökning: "PBN"

Visar resultat 11 - 15 av 22 avhandlingar innehållade ordet PBN.

  1. 11. IL-6 and GLP-1 in body fat regulating parts of the CNS in healthy mice

    Författare :Fredrik Anesten; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IL-6; IL-6Rα; GLP-1; obesity; hypothalamus; brainstem; tanycytes; immunohistochemistry;

    Sammanfattning : It has previously been shown that mice lacking interleukin-6 (IL-6) develop mature onset obesity. The weight-suppressing effects of IL-6 have been assumed to be exerted at a central level, as supported by the fact that ICV- injections, but not peripheral injections of IL-6, increases energy expenditure and decreases body fat in rodents. LÄS MER

  3. 12. Handling demand-capacity imbalances in aerial vehicle traffic

    Författare :Leonid Sedov; Tobias Andersson Granberg; Valentin Polishchuk; Joost Ellerbroek; Linköpings universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY;

    Sammanfattning : It is expected that the number of drones used in both commercial and leisure operations will grow significantly in the coming years, which raises the need for a solid framework for management of this traffic. Unmanned traffic management (UTM) is a system for handling autonomous drone flights over urban areas. LÄS MER

  4. 13. Neurogenesis, neural stem cells and nitric oxide in neuroinflammation

    Författare :Alexandre I Danilov; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Neurogenesis; neuronal stem cells; nitric oxide; Multiple Sclerosis; EAE; brain trauma;

    Sammanfattning : We investigated whether nitric oxide (NO) is produced in MS patients, determining the concentrations of its oxidation products (NOx) in CSF. The total levels of NOx in CSF were significantly increased in all MS groups as compared to healthy controls and tension headache patients. LÄS MER

  5. 14. Altering the fetal programming of the HPA axis and the consequences in the adult auditory system

    Författare :Amzad Hossain; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Prenatal glueocorticoid (GC) has been associated with a variety of alterations in the adult offspring. Hypothalamo-Pituitary-Adrenal (HPA) axis, which is the key regulator for almost all kind of neuroendocine function and behavior, is highly susceptible to prenatal exposure to excess GC during development. LÄS MER

  7. 15. Teratogenicity as a consequence of drug-induced embryonic cardiac arrhythmia : Common mechanism for almokalant, sotalol, cisapride, and phenytoin via inhibition of IKr

    Författare :Anna-Carin Sköld; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; IKr; delayed rectifying K channel; embryonic cardiac arrhythmia; teratogenicity; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; Toxicology; toxikologi;

    Sammanfattning : During the last years, drugs that prolong the repolarisation phase of the myocardial action potential, due to inhibition of the rapid component of the delayed-rectifying potassium channel (IKr) have been in focus. In addition to arrhythmogenic potential, selective Ikr-blockers have also been shown to be embryotoxic and teratogenic in animal studies. LÄS MER