Sökning: "PARP inhibitors"

Visar resultat 11 - 15 av 21 avhandlingar innehållade orden PARP inhibitors.

1. 11. Coagulation and inflammation in experimental endotoxemia in vitro and in vivo : monitoring method and effects of nicotinamide

   Författare :Johanna S Ungerstedt; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Sepsis; endotoxin; tissue factor; cytokines; nicotinamide; coagulation; inflammation;

   Sammanfattning : In gram negative sepsis, endotoxin from the bacterial membrane elicits proinflammatory and procoagulant host responses. Sepsis and its frequent complication disseminated intravascular coagulation (DIC) are leading causes of morbidity and mortality in the intensive care. LÄS MER

3. 12. Pro-senescence therapy by targeting MYC and its network as a strategy to combat cancer

   Författare :Fan Zhang; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Cancer is defined as abnormal cell proliferation with the potential of metastasis and is an increasing threat to global health as the population becomes older. Cancer is triggered by gain-of-function mutations in oncogenes and loss of function mutations in tumor suppressor genes. LÄS MER

4. 13. Retinal tumorigenesis and neurodegeneration : strategies to promote tumor cell death and support retinal cell survival to preserve vision

   Författare :Tanzina Mollick; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Our vision is central to our quality of life enabling us to interact with our environment and lead productive lives. The ability to see begins in the retina, one of the paramount features of the eye, as it takes on the task of converting light signals to nerve impulses that are relayed to the visual centers of the brain. LÄS MER

5. 14. 5-Fluorouracil mediated cell death signaling
 in colon carcinoma cells

   Författare :Birce Akpinar; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Colorectal cancer (CRC) is the third most common form of cancer in the world. 5- Fluorouracil (5-FU) belongs to the fluoropyrimidine-type of drugs and is commonly used in the treatment of several solid tumors. It has become the mainstay of CRC treatment at stage III and high risk stage II, either alone or in combination with other drugs. LÄS MER

7. 15. On the role of bioactive sphingolipids and their metabolizing enzymes in cancer

   Författare :Dilruba Ahmed; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Ceramide is a family of closely related molecules, which are presumed to be in the center of sphingolipid metabolism. Among sphingolipid metabolites, several ceramide subspecies and sphingosine induce apoptosis, cell cycle arrest and death, whereas sphingosine 1-phosphate (S1P) mediates cell proliferation, invasion, angiogenesis and metastasis. LÄS MER