Sökning: "PAI-2"

Visar resultat 1 - 5 av 10 avhandlingar innehållade ordet PAI-2.

  1. 1. The significance of urokinase-type plasminogen activator (u-PA) in tumour growth and Linomide-induced upregulation of u-PA's endogenous inhibitor PAI-2

    Författare :Anita Billström; Lund Obstetrik och gynekologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; reproduction; andrology; gynaecology; Obstetrics; roquinimex; Linomide; cancer; prostate cancer; PAI-2; plasmin; Plasminogen activators; u-PA; sexuality; Obstetrik; gynekologi; andrologi; reproduktion; sexualitet; Immunology; serology; transplantation; Immunologi; serologi;

    Sammanfattning : The progressive process of tumour invasion and generation of metastases is the primary cause of death for most patients with cancer. Some of the regulatory components of this progressive process are adhesion, migration, and proteolysis. LÄS MER

  3. 2. Biochemical and Epidemiological Studies of Early-Onset and Late-Onset Pre-Eclampsia

    Författare :Anna-Karin Wikström; Matts Olovsson; Ulf Eriksson; Solveig Norden-Lindeberg; Göran Berg; Uppsala universitet; []
    Nyckelord :Obstetrics and gynaecology; pre-eclampsia; proteinuria; albumin-creatinine ratio; ischaemic heart disease; angiogenesis; sFlt1; oxidative stress; isoprostane; PAI-1; PAI-2; Obstetrik och kvinnosjukdomar;

    Sammanfattning : Biochemical and epidemiological aspects of pre-eclampsia were investigated, with the main focus on possible pathophysiological differences between early-onset and late-onset disease.In pre-eclamptic women poor correlation was found between albumin-creatinine ratio (ACR) in a random urine sample and total amount of albumin in a 24-hour urine collection. LÄS MER

  4. 3. Experimental and Clinical Studies of Oxidative Stress in Pre-Eclampsia

    Författare :Peppi Nash; Ulf Eriksson; Matts Olovsson; Leif Jansson; Lucilla Poston; Uppsala universitet; []
    Nyckelord :Obstetrics and gynaecology; Pre-eclampsia; Oxidative stress; Diabetes; Placenta; Rat; Antioxidants; Suramin; Vitamin E; Vitamin C; PAI-1; PAI-2; Obstetrik och kvinnosjukdomar;

    Sammanfattning : Impaired placentation and oxidative stress are proposed to play major roles in the pathogenesis of pre-eclampsia (PE). It has recently been pointed out that PE might be more than one disease and may have several different pathogeneses. LÄS MER

  5. 4. Invasion promoting factors in endometriotic and endometrial tissue

    Författare :Christina Bruse; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Endometriosis; endometrium; PF; tPA; uPA; uPAR; PAI-1; PAI-2; IL-1beta; IL-6; TNFalpha.;

    Sammanfattning : Endometriosis is a common gynaecologic disorder, affecting women of fertile age with pelvic pain and infertility, and is characterized by the presence of endometrial glands and stroma outside the uterine cavity. Retrograde shed endometrial fragments are presumed to adhere to pelvic structures and grow invasively, thereby creating endometriotic tissue. LÄS MER

  7. 5. Plasminogen activator inhibitor type 2 : a unique serpin with two mobile loops

    Författare :Sergei Lobov; Umeå universitet; []
    Nyckelord :;

    Sammanfattning : The superfamily of serine protease inhibitors (serpins) is a large group of proteins with diverse functions but a common tertiary structure. Active serpins are highly metastable molecules. Metastability is the property underlying the success and ubiquitousness of serpins. LÄS MER