Sökning: "PACAP"

Visar resultat 21 - 25 av 25 avhandlingar innehållade ordet PACAP.

  1. 21. Aspects of aqueous humor dynamics : Studies in vivo and in vitro

    Författare :Maria Samuelsson-Almén; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology and anatomy; Aqneous humor flow; intraocular pressure; adenylate cyclase; nonpigmented ciliary epithelium; pituitary adenylate cyclase-activating polypeptide; vasoactive intestinal polypeptide; dopamine; prostaglandin; Fysiologi och anatomi; Physiology and pharmacology; Fysiologi och farmakologi; Physiology; fysiologi;

    Sammanfattning : The purpose of the present investigation was to study the effects of PGF2α-l-isopropylester, some neuropeptides, and pharmacological agents on aqueous humor dynamics and intraocular pressure (IOP) in vivo and on adenylate cyclase activity in the nonpigmented ciliary epithelium (NPE) in vitro.Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal polypeptide (VIP) caused a dose-dependent increase in cAMP formation, indicating that the NPE contains receptors for PACAP and VIP coupled to adenylate cyclase activation. LÄS MER

  3. 22. The neuropeptide VIP and the IL-6 family of cytokines in bone : effects on bone resorption, cytokine expression and receptor signalling in osteoblasts and bone marrow stromal cells

    Författare :Emma Persson; Ulf Lerner; Andreas Kindmark; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; osteoblast; bone resorption; cytokines; IL-6; neuropeptides; VIP; transcription factor; Cell biology; Cellbiologi;

    Sammanfattning : Bone tissue is continuously degraded and rebuilt to respond to the needs of the body. Cells of the osteoblast lineage are responsible for the formation of bone, whereas the resorption of bone tissue is carried out by osteoclasts. LÄS MER

  4. 23. Vascular effects of neuropeptides and UDP-β-S and alterations after stroke

    Författare :André Erdling; Neurokirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The aim of this thesis is to investigate the changes in vasoactive intestinal peptide (VIP) and calcitonin gene-related peptide(CGRP) and P2Y6-mediated signaling following experimental subarachnoid hemorrhage (SAH) and transient middle cerebral artery occlusion (tMCAO). VIP and CGRP are among the most powerful vasodilators known to man while P2Y6 mediates strong vasoconstriction in cerebral blood vessels. LÄS MER

  5. 24. Deciphering the role of genetics and circadian rhythm in cluster headache

    Författare :Carmen Fourier; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cluster headache (CH) is a complex neurovascular disorder with a distinct circadian attack pattern. Although many aspects of the disease’s pathophysiology remain to be elucidated, it is likely caused by a combination of different genetic and environmental risk factors. LÄS MER

  7. 25. Ephrins off the beaten path

    Författare :Johan Holmberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The Orchestration of cell-cell interactions is crucial to the developing embryo and the adult organism. Intercellular communication is to a large extent controlled by signalling events downstream of receptor tyrosine kinases (RTKs). Ligands for RTKs are often soluble and confer long distance information to the receptor expressing cell. LÄS MER