Sökning: "P3"
Visar resultat 1 - 5 av 48 avhandlingar innehållade ordet P3.
1. Specific language impairment: Neurophysiological studies of children and their parents
Sammanfattning : Specific language impairment (SLI) is commonly described as a condition where a child with otherwise normal development and hearing does not acquire language as expected. Children with SLI often have a family history of language disorders. The aetiology is poorly understood. LÄS MER
2. Intracellular signaling of phosphorylated insitol compounds : a study in pancreatic beta-cells and hippocampal neurons
Sammanfattning : The family of phosphorylated inositol compounds consists of soluble cytosolic inositol phosphates and insoluble inositol phospholipids, localized in cellular membranes and the nuclear matrix. Although inositol phospholipids only account for 5-10% of total plasma membrane lipids, these compounds and their inositol phosphate derivatives play an important role in a broad range of cellular processes including intracellular Ca 2+ signalling, ion channel regulation, vesicle trafficking, both exo- and endocytosis, cell growth and apoptosis. LÄS MER
3. Design and Synthesis of Acyclic and Macrocyclic Peptidomimetics as Inhibitors of the Hepatitis C Virus NS3 Protease
Sammanfattning : Hepatitis C is a blood-borne disease affecting 130-170 million people worldwide. The causative agent, hepatitis C virus (HCV), infects the liver and is the major reason for chronic liver disease worldwide. The HCV NS3 protease, a key enzyme in the virus replication cycle, has been confirmed to be an important target for drug development. LÄS MER
4. Design and Synthesis of Inhibitors Targeting BACE-1, an Aspartic Protease Involved in the Pathogenesis of Alzheimer’s Disease
Sammanfattning : Alzheimer’s disease (AD) is the most common form of dementia, occurring in an estimated 24 million people worldwide. Accumulation of amyloid-b peptides leads to development of plaques in the brain, which eventually stimulates hyperphosphorylation of tau proteins leading to tangles. This is believed to play a crucial role in the pathology of AD. LÄS MER
5. Challenges in Partially Automated Driving : A Human Factors Perspective
Sammanfattning : The technological development in recent years is currently reflected in the implementation of more and more advanced driver assistance systems (ADAS). A clear example is found in the automated driving systems being marketed today. LÄS MER