Sökning: "P2X7"

Visar resultat 1 - 5 av 9 avhandlingar innehållade ordet P2X7.

  1. 1. Immunoglobulin Gene Analysis in Chronic Lymphocytic Leukemia : Characterization of New Prognostic and Biological Subsets

    Författare :Gerard Tobin; Richard Rosenquist; Christer Sundström; Anna Laurell; Nicholas Chiorazzi; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; chronic lymphocytic leukemia; immunoglobulin genes; VH3-21; CDR3; P2X7; Genetik; Clinical genetics; Klinisk genetik;

    Sammanfattning : Recent studies have shown that the somatic mutation status of the immunoglobulin (Ig) VH genes can divide chronic lymphocytic leukemia (CLL) into two prognostic subsets, since cases with mutated VH genes display superior survival compared to unmutated cases. Biased VH gene usage has also been reported in CLL which may reflect antigen selection. LÄS MER

  3. 2. Statin-induced cellular effects mediated by the P2X7 receptor

    Författare :Oras Mistafa; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cholesterol-lowering statins have been shown to inhibit growth of different cancer cells both in vitro and in vivo. Epidemiological studies also indicate a chemopreventive effect of statins. We have investigated the effect of statins on Akt/protein kinase B signaling and their sensitizing effect of cytostatic drugs. LÄS MER

  4. 3. Akt signaling and coordinated changes in the distribution and expression of Akt-regulating phosphatases

    Författare :Aram Ghalali; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cancer is one of the major causes of death worldwide. The PI3K/Akt signaling pathway is up-regulated in a variety of human cancers. Akt is an important signaling molecule in cellular survival pathways. Activated Akt (pAkt) is able to induce protein synthesis pathways, and is therefore a key protein involved in growth and prevention of apoptosis. LÄS MER

  5. 4. Cell death and clearance - studies of human neutrophils from blood and tissue

    Författare :Karin Christenson; Göteborgs universitet; []
    Nyckelord :neutrophils; apoptosis; transmigration; phagocytes;

    Sammanfattning : Neutrophils are phagocytic cells that typically migrate from circulation to tissues in order to combat microbial invasion. The journey from blood to tissue involves mobilization of intracellular organelles which results in modifications of surface markers (e.g. LÄS MER

  7. 5. GLIAL HEMICHANNELS: A NEW ROUTE FOR CHEMICAL COMMUNICATION IN BRAIN

    Författare :Malin Stridh; Göteborgs universitet; []
    Nyckelord :astrocyte; antioxidant; connexin; hemichannel; glutathione; efflux; glutamate;

    Sammanfattning : The extracellular neurochemistry determines normal brain function and the faith of neurons after insults such as stroke. This thesis concerns the effect of extracellular events related to intense neuronal stimulation and stroke, i.e. LÄS MER