Sökning: "P2 receptor"

Visar resultat 16 - 20 av 24 avhandlingar innehållade orden P2 receptor.

  1. 16. Studies on 15-lipoxygenase in dendritic cells and leukotriene receptors in Hodgkin lymphoma

    Författare :Frida Schain; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Classical Hodgkin lymphoma (cHL) is histologically characterized by a minority of malignant cells, the so-called Hodgkin-Reed Sternberg (H-RS) cells, surrounded by inflammatory cells such as T lymphocytes, eosinophils, macrophages and mast cells. It is generally believed that various molecules released by the H-RS cells are of major importance in the pathophysiology of cHL. LÄS MER

  3. 17. Regulation of insulin-like growth factor-II in human liver

    Författare :Henrik von Horn; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :IG17-II; IGF2; IGFBPs; liver; hepatoblastoma; GH; hypoxia;

    Sammanfattning : Insulin-like growth factors-I and -II (IGF-I and -II) are mitogens in a number of cell types and also have insulin-like actions. IGF-II has an autocrine role in a variety of malignancies; and hypoglycemia is well documented in conditions associated with elevated IGF-II precursor forms in the circulation. LÄS MER

  4. 18. Plasma membrane order; the role of cholesterol and links to actin filaments

    Författare :Jelena Dinic; Ingela Parmryd; Gerrit van Meer; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Membrane Organization; Lipid rafts; Actin; Laurdan; di-4-ANEPPDHQ; Cholesterol; T cell signaling; Colocalization; Generalized Polarization; Cell Biology; cellbiologi;

    Sammanfattning : The connection between T cell activation, plasma membrane order and actin filament dynamics was the main focus of this study. Laurdan and di-4-ANEPPDHQ, membrane order sensing probes, were shown to report only on lipid packing rather than being influenced by the presence of membrane-inserted peptides justifying their use in membrane order studies. LÄS MER

  5. 19. Regulation of docking and priming in pancreatic α- and β-cells

    Författare :Muhmmad Omar-Hmeadi; Sebastian Barg; Patrick MacDonald; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type-2 diabetes; glucagon; insulin; somatostatin; exocytosis;

    Sammanfattning : The secretion of islet hormones from endocrine cells of the pancreas plays vital roles in maintaining glucose homeostasis. Dysfunction of these cells leads to diabetes, a devastating metabolic disorder affecting millions worldwide, but underlying mechanisms remain poorly understood. LÄS MER

  7. 20. The role of substance P in respiratory control in the newborn : effects of morphine and nicotine

    Författare :Jonas Berner; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : We breathe in order to maintain oxygen, carbon dioxide and pH levels within the physiological range in response to the metabolic demands of the body. To achieve this, the respiratory control system is dependent on input from peripheral and/ central chemosensitive areas and on participation of different neuromodulator systems. LÄS MER