Sökning: "P Karlsson"
Visar resultat 11 - 15 av 47 avhandlingar innehållade orden P Karlsson.
11. Health economics and its measures in rheumatoid arthritis
Sammanfattning : Objectives: To study: (I) the impact on cost-utility analyses of applying different national EuroQol 5-Dimensions (EQ-5D) preference sets; (II and III) whether, in methotrexate-refractory, early rheumatoid arthritis (RA), the addition of infliximab results in superior health-related quality of life (HRQoL) and may be considered cost-effective, as compared to adding sulfasalazine and hydroxychloroquine; (IV) how costs relate to disability (measured by the health-assessment questionnaire, HAQ), disease activity (28-joint disease activity score, DAS28) and HRQoL (EQ-5D) in RA. Methods: In the observational SSATG register, one-year quality-adjusted life-year (QALY) accumulation of two interventions was compared according to the UK, US, or Danish EQ-5D preference sets. LÄS MER
12. Epidemiological and experimental studies on sarcoma with focus on gastrointestinal stromal tumors
Sammanfattning : Sarcoma is the common denominator for malignant tumors of mesenchymal origin. Sarcomas encompass almost 100 diagnoses with different histology, molecular features and natural history, and may present in any part of the body. The most common sarcoma in the abdomen is the gastrointestinal stromal tumor (GIST). LÄS MER
13. Appetite regulating neuropeptides in alcohol addiction : focus on melanin concentrating hormone and its mch1-receptor
Sammanfattning : Current treatment options for alcohol use disorders are limited in number and have limited efficacy. It is therefore important to find new, more effective medications. LÄS MER
14. Sentinel node based immunotherapy of cancer
Sammanfattning : The tumor draining lymph node, the sentinel node, is regarded as a valuable station for staging and evaluating prognoses for patients with cancer. The object of this thesis was to investigate the immune response against solid cancers and to explore the sentinel node as a source of naturally occurring tumor reactive lymphocytes, for further activation and expansion in vitro for the purpose of immunotherapy. LÄS MER
15. On evaluation of organ damage in perinatal asphyxia : an experimental and clinical study
Sammanfattning : Leakage of intracellular enzymes such as alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) signalling multi organ dysfunction (MOD) is seen together with hypoxic ischemic encephalopathy (HIE) after perinatal asphyxia. Hypothermia (HT) can attenuate HIE following perinatal asphyxia and hypoxia-ischemia (HI) but the neuroprotective efficacy falls dramatically the longer the delay in initiating HT. LÄS MER