Sökning: "Pär Ewing"

Hittade 1 avhandling innehållade orden Pär Ewing.

1. 1. A novel technology for studying the disposition of drugs and toxicants in the lung : short inhalation exposures of the isolated and perfused rat lung to respirable dry particle aerosols

   Författare :Pär Ewing; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Aerosol; inhalation; rat; lung; absorption; drugs; carcinogen; particles;

   Sammanfattning : The disposition of solutes following the deposition of inhaled substances in the lung is a complex process that proceeds along parallel paths; passive diffusion of solutes through the air/blood barrier and local metabolism followed by blood-borne clearance to the circulation. Using the isolated and perfused lung (IPL) the pulmonary disposition of inhaled particles can be studied in great detail without interference from distal organs and systemic exposure. LÄS MER