Sökning: "Oxaliplatin"

Visar resultat 1 - 5 av 29 avhandlingar innehållade ordet Oxaliplatin.

1. 1. Neurotoxic side effects and impact on daily life in patients with colorectal cancer with adjuvant oxaliplatin-based chemotherapy

   Författare :Jenny Drott; Carina Berterö; Hans Starkhammar; Karin Kjellgren; Sussanne Börjeson; Yvonne Wengström; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer care; Cancer nursing; Colorectal cancer; Neurotoxicity; Neuropathy; Oxaliplatin; Chemotherapy; Patient-reported outcomes; Health; Qualitative study; Longitudinal study; mHealth;

   Sammanfattning : Introduction: Colorectal cancer (CRC) is one of the most common cancers globally. Chemotherapeutic drugs are frequently used in postoperative treatment. The platinum compound oxaliplatin (OXA) is an option for adjuvant treatment of patients with resected CRC, and has been shown to improve survival. OXA-induced neurotoxic side effects are common (e. LÄS MER

3. 2. Chemoradiation in Gastrointestinal Cancer

   Författare :Adalsteinn Gunnlaugsson; Bröstcancer-genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biliary tract cancer; capecitabine; cholangiocarcinoma; chemoradiation; colon cancer; enteritis 5-fluorouracil; gallbladder cancer; oxaliplatin; pancreatic cancer; rectal cancer.;

   Sammanfattning : Locally advanced inextirpable gastrointestinal cancer has poor prognosis and is associated with high morbidity. One treatment option is to use radiotherapy, often combined with chemotherapy (chemoradiation), either as preoperative treatment to facilitate surgery or in the palliative setting to relieve symptoms. LÄS MER

4. 3. Nucleic Acids as Drugs and Drug Targets With Focus on Anticancer Active Platinum Complexes and Small Interfering RNAs

   Författare :Hanna Hedman; Biokemi och Strukturbiologi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Anticancer drugs; platinum complexes; cisplatin; oxaliplatin; nucleic acid; RNA; DNA; siRNA; thermodynamic stability; mass spectrometry; MALDI-MS; chemical probing; luciferase assay;

   Sammanfattning : To ensure that patients receive a safe and effective treatment, it is important to understand how drugs interact with and affect molecules within a cell. Here, evaluation of platinum based drugs and their ability to interfere with nucleic acid functions is presented. LÄS MER

5. 4. HIPECology : Aspects of Postoperative Morbidity Following the HIPEC Procedure

   Författare :Paul Dranichnikov; Peter Cashin; Wilhelm Graf; Martin Rutegård; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CRS; HIPEC; readmission; EPIC; coagulopathy; VTE; goal-directed therapy GDT ; postoperative hemorrhage; oxaliplatin.; Surgery; Kirurgi; Oncology; Onkologi;

   Sammanfattning : Peritoneal surface malignancy (PM), regardless of the dissemination site, was once considered a terminal condition.  However, the introduction of a surgical approach with cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) with or without early intraperitoneal chemotherapy (EPIC) shifted the attitude from managing the symptoms of PM to disease treatment with curative intent. LÄS MER

7. 5. Nucleic Acids as Drug Targets - Influence of Platinum Complexes on Duplex Stability and Binding Kinetics

   Författare :Christopher Polonyi; Biokemi och Strukturbiologi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Anticancer drugs; platinum complexes; cisplatin; oxaliplatin; nucleic acid; RNA; DNA; duplex melting; thermodynamic stability; kinetics; non-coding RNA; miRNA; siRNA; wobble base pair; loop; BRCA1; mimic; luciferase assay;

   Sammanfattning : Gaining a detailed understanding of how human cells are affected by metal-based drugs is crucial, since these drugs have shown great potential in cancer treatment. Cisplatin is used to treat many different types of cancer, e.g. testicular, ovarian, melanoma, bladder, non-small cell lung cancer, small cell lung cancer, myelomas and lymphomas. LÄS MER