Sökning: "Oral glucose tolerance test"

Visar resultat 6 - 10 av 75 avhandlingar innehållade orden Oral glucose tolerance test.

1. 6. Islet hormonal hypersecretion and metformin’s effect on islet hormonal secretion studied in vitro and in vivo

   Författare :Quan Wen; Anders Forslund; Hannes Manell; Hjalti Kristinsson; Lisa Juntti-Berggren; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; alpha cell; carboxypeptidase E; childhood obesity; DRP-1; free fatty acids; glucagon secretion; glucose metabolism; glucose stimulated insulin secretion; human islets; hyperinsulinemia; metformin; mitochondrial fission; oral glucose tolerance test OGTT ; prohormone convertase; proinsulin; proinsulin to insulin ratio PI:I ;

   Sammanfattning : Childhood obesity has surged globally. Elevated levels of free fatty acids contribute to hyperinsulinemia, hyperproinsulinemia, and hyperglucagonemia connected with both obesity and type 2 diabetes mellitus (T2DM). Metformin has beneficial effects on islets by influencing metabolism and reducing stress-induced cell death. LÄS MER

3. 7. Characterization of Impaired Glucose Tolerance - Insulin Sensitivity, Islet Function and Metabolic Risk Factors

   Författare :Hillevi Larsson; Malmö Institutionen för kliniska vetenskaper; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endocrinology; muscle fiber type; androgen activity; proinsulin; glucagon; insulin secretion; insulin sensitivity; Impaired glucose tolerance; type 2 diabetes; sekretion; diabetologi; Endokrinologi; diabetology; secreting systems;

   Sammanfattning : This thesis presents a three-year prospective study on metabolic characteristics of impaired glucose tolerance (IGT) and the regulation of insulin sensitivity versus islet function in relation to changes in glucose tolerance. 108 non-diabetic women aged 57-58 years were randomly selected from a population of women born in 1935 with a high prevalence of IGT. LÄS MER

4. 8. Oral glucose tolerance test as a prognostic tool in patients with acute coronary syndrome

   Författare :Catarina Djupsjö; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Background: Disturbances of glucose metabolism such as type 2 diabetes and impaired glucose tolerance are established risk factors for cardiovascular disease and mortality. The disturbances lead to hyperglycaemia and the most common methods to diagnose hyperglycaemia are HbA1c, oral glucose tolerance test (OGTT) and fasting plasma glucose (FPG). LÄS MER

5. 9. Mechanism-Based Modeling of the Glucose-Insulin Regulation during Clinical Provocation Experiments

   Författare :Petra Jauslin-Stetina; Mats Karlsson; Nicolas Frey; Philippe Jacqmin; Uppsala universitet; []
   Nyckelord :Pharmacokinetics Pharmacotherapy; Glucose homeostasis; Type 2 diabetes; IVGTT; OGTT; Meal test; Circadian variation; Mechanism-based; NONMEM; Farmakokinetik Farmakoterapi;

   Sammanfattning : Type 2 diabetes is a complex chronic metabolic disorder characterized by hyperglycemia associated with a relative deficiency of insulin secretion and a reduced response of target tissues to insulin. Considerable efforts have been put into the development of models describing the glucose-insulin system. LÄS MER

7. 10. Impaired glucose tolerance in ischemic heart disease

   Författare :Loghman Henareh; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Diabetes mellitus; myocardial infarction; atherosclerosis; endothelial dysfunction; inflammation; microalbumiuria; left ventricular hypertrophy; tissue Doppler.;

   Sammanfattning : Background: Diabetes mellitus (DM) and impaired glucose tolerance test (IGT) are well known risk factors for cardiovascular disease (CVD). Individuals with IGT, a prediabetic state, are asymptomatic during many years and they often remain undiagnosed until they have developed overt diabetes or cardiovascular complications. LÄS MER