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Visar resultat 1 - 5 av 7 avhandlingar som matchar ovanstående sökkriterier.

1. 1. The Immune Response to One-Lung Ventilation : Clinical and Experimental Studies

   Författare :Thomas Schilling; Göran Hedenstierna; Hans Hedenström; Thomas Hachenberg; Sven-Erik Ricksten; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; One-lung ventilation; open thoracic surgery; ventilation-induced lung injury; alveolar immune response; bronchoalveolar lavage; propofol; desflurane; cytokines; animal model; mRNA; RT-PCR; Medical laboratory science; Medicinsk laboratorievetenskap; anestesiologi; Anaesthesiology;

   Sammanfattning : One-lung ventilation (OLV) as an established procedure during thoracic surgery may be injurious in terms of increased mechanical stress characterised by alveolar cell stretch and overdistension, increased cyclic tidal recruitment of alveolar units, compression of alveolar vessels and increased pulmonary vascular resistance. This may result in ventilation-induced lung injury with pro-inflammatory cytokine production, leukocyte recruitment and neutrophil-dependent tissue destruction. LÄS MER

3. 2. Pathophysiological and Histomorphological Effects of One-Lung Ventilation in the Porcine Lung

   Författare :Alf Kozian; Göran Hedenstierna; Thomas Hachenberg; Filip Freden; Sten Walther; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alveolar Recruitment Manoeuvre; One-Lung Ventilation; Lung Protective Ventilation; Tidal Volume; Computed Tomography; Tidal Recruitment; Animal Model; Open Thoracic Surgery; Ventilation Perfusion Distribution; Single Photon Emission Computed Tomography; Diffuse Alveolar Damage; Medical laboratory science; Medicinsk laboratorievetenskap; Anestesiologi; Anaesthesiology;

   Sammanfattning : Thoracic surgical procedures require partial or complete airway separation and the opportunity to exclude one lung from ventilation (one-lung ventilation, OLV). OLV is commonly associated with profound pathophysiological changes that may affect the postoperative outcome. LÄS MER

4. 3. Open lung concept in high risk anaesthesia : Optimizing mechanical ventilation in morbidly obese patients and during one lung ventilation with capnothorax

   Författare :Henrik Reinius; Filip Fredén; Johan Petersson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anaesthesia; mechanical ventilation; atelectasis; morbidly obese; one-lung ventilation; PEEP; recruitment maneuver; spirometry; EIT; Anestesiologi och intensivvård; Anaesthesiology and Intensive Care;

   Sammanfattning : Formation of atelectasis, defined as reversible collapse of aerated lung, often occurs after induction of anaesthesia with mechanical ventilation. As a consequence, there is a risk for hypoxemia, altered hemodynamics and impaired respiratory system mechanics. LÄS MER

5. 4. Remote Ischemic Preconditioning and its Effects on the Respiratory System

   Författare :Astrid Bergmann; Anders Larsson; Göran Hedenstierna; Thomas Hachenberg; Ola Winsö; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; one-lung ventilation; ventilation-induced lung injury; alveolar immune response; remote ischemic preconditioning; exhaled nitric oxide; animal model; Anestesiologi och intensivvård; Anaesthesiology and Intensive Care;

   Sammanfattning : Mechanical ventilation in itself can lead to pulmonary damage, and one-lung ventilation (OLV), necessary for thoracic surgery, accentuates this injury. Remote ischemic preconditioning (RIP) is a potential tool to reduce lung injury after mechanical ventilation, including OLV.  However, current data on pulmonary RIP-effects are contradictory. LÄS MER

7. 5. Cardiopulmonary adaption to one-lung ventilation and neoadjuvant therapy during treatment of esophageal cancer

   Författare :Mikael Lund; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Introduction: Esophagectomy is the main form of curative treatment for esophageal cancer and has a high morbidity rate. Neoadjuvant chemo- (CT) or chemoradiotherapy (CRT) is employed to increase long-term survival. To improve perioperative care the effects of measures taken to improve surgical exposure i.e. LÄS MER