Sökning: "Olle Stål"
Visar resultat 16 - 18 av 18 avhandlingar innehållade orden Olle Stål.
16. Elucidating the role of 17β hydroxysteroid dehydrogenase type 14 in normal physiology and in breast cancer
Sammanfattning : Oestrogens play key roles in the development of the majority of breast tumours, a fact that has been exploited successfully in treating breast cancer with tamoxifen, which is a selective oestrogen receptor modulator. In post-menopausal women, oestrogens are synthesised in peripheral hormone-target tissues from adrenally derived precursors. LÄS MER
17. DNA repair pathways and the effect of radiotherapy in breast cancer
Sammanfattning : A large proportion of breast cancer patients are treated with radiotherapy. Ionising radiation induces different DNA damages, of which double-strand breaks are the most severe. They are mainly repaired by homologous recombination or non-homologous end-joining. Different protein complexes have central roles in these repair processes. LÄS MER
18. The receptor tyrosine kinase Met and the protein tyrosine phosphatase PTPN2 in breast cancer
Sammanfattning : Breast cancer is the most common form of cancer in women worldwide and the second leading cause of cancer death. It is a heterogeneous disease and is subdivided into different subtypes, all with different treatment responses and survival outcomes. LÄS MER