Sökning: "Okazaki fragment"

Hittade 2 avhandlingar innehållade orden Okazaki fragment.

1. 1. Structure of eukaryotic DNA polymerase epsilon and lesion bypass capability

   Författare :Nasim Sabouri; Erik Johansson; Lars Thelander; Ola Hammarsten; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; DNA polymerase epsilon; DNA replication; Okazaki fragment; Translesion synthesis; DNA lesion; dNTP; Biochemistry; Biokemi;

   Sammanfattning : To transfer the information in the genome from mother cell to daughter cell, the DNA replication must be carried out only once and with very high fidelity prior to every cell division. In yeast there are several different DNA polymerases involved in DNA replication and/or DNA repair. LÄS MER

3. 2. Markers predicting sensitivity to polyamine depletion in human breast cancer cell lines

   Författare :Veronica Johansson; Biologiska institutionen; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; PCNA; PAO; human breast cancer cell lines; FEN1; DNA strand breaks; DNA ligase I; apoptosis; Bcl-2; polyamine analogues; pRb;

   Sammanfattning : In spite of different treatment strategies today, breast cancer mortality is still high and new treatments are therefore needed. Potential new treatments can be found among the polyamine analogues. Polyamine analogues can be used in cancer treatment as cancer cells have a higher requirement for polyamines than the surrounding healthy tissue. LÄS MER