Sökning: "OXPHOS"

Visar resultat 11 - 15 av 31 avhandlingar innehållade ordet OXPHOS.

  1. 11. MicroRNA and energy metabolism in gastrointestinal tumors

    Författare :Wen-Kuan Huang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : MicroRNAs (miRNAs) contribute to cancer development and drug resistance via cellular biological processes, including metabolic pathways. Energy metabolism plays a significant role to maintain tumor proliferation in gastrointestinal (GI) cancers. However, the roles of miRNAs and energy metabolism in GI cancers are not fully understood. LÄS MER

  3. 12. Protein and lipid interactions within the respiratory chain : Studies using membrane-mimetic systems

    Författare :Tobias Nilsson; Peter Brzezinski; Petra Hellwig; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Cytochrome c oxidase; ATP synthase; Bioenergetics; membrane-mimetics; Rcf1; liposomes; oxidative phosphorylation; lipids; protein-protein interactions; Biochemistry; biokemi;

    Sammanfattning : Energy conversion from nutrients to ATP is a vital process in cells. The process, called oxidative phosphorylation (OXPHOS) is performed by a combination of membrane-bound proteins. These proteins have been studied in great detail in the past, however much is still unknown about how they interact with each other. LÄS MER

  4. 13. Environmentally relevant chemical disruptors of oxidative phosphorylation in Baltic Sea biota : Exposure and toxic potentials

    Författare :Anna-Karin Dahlberg; Lillemor Asplund; Åke Bergman; Göran Marsh; Patrik Andersson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Oxidative phosphorylation; OH-PBDEs; MeO-PBDEs; PBDEs; long-tailed duck Clangula hyemalis ; Baltic herring Clupea harengus ; Baltic blue mussel Mytilus trossulus x Mytilus edulis ; Baltic Sea; miljökemi; Environmental Chemistry;

    Sammanfattning : This thesis focuses on toxicity and occurrence of hydroxylated polybrominated diphenyl ethers (OH-PBDEs) in Baltic Sea biota. The aims were to assess OH-PBDEs potency for disruption of oxidative phosphorylation (OXPHOS) and determine their and related compounds exposure in Baltic blue mussel, herring and long-tailed duck. LÄS MER

  5. 14. Life without mitochondrial DNA : studies of transgenic mice

    Författare :Jianming Wang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :mitochondrial disease; mitochondrial DNA mtDNA ; mitochondrial transcripton factor A Tfam ; cre-loxP; conditional knockout; transgenic; mitochondrial cardiomyopathy; apoptosis;

    Sammanfattning : Mitochondrial DNA (mtDNA) is a closed circular DNA genome that resides in the mitochondrial network. Mutations of mtDNA cause spontaneous and hereditary disorders known as mitochondrial diseases. Mitochondrial transcription factor A (Tfam) is a key factor for transcription of mtDNA in vitro. LÄS MER

  7. 15. Multi-dimensional omics approaches to dissect natural immune control mechanisms associated with RNA virus infections

    Författare :Anoop Tholamplackil Ambikan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In recent decades, global health has been challenged by emerging and re-emerging viruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), human immunodeficiency viruses (HIV-1), and Crimean–Congo hemorrhagic fever virus (CCHFV). Studies have shown dysregulations in the host metabolic processes against SARS-CoV2 and HIV-1 infections, and the research on CCHFV infection is still in the infant stage. LÄS MER