Sökning: "OPRM1"

Visar resultat 6 - 8 av 8 avhandlingar innehållade ordet OPRM1.

  1. 6. Forensic Toxicological Aspects of Tramadol : Focus on Enantioselective Drug Disposition and Pharmacogenetics

    Författare :Pernilla Haage; Fredrik Kugelberg; Robert Kronstrand; Espen Molden; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : One of the most difficult parts in forensic toxicology is to interpret obtained drug concentrations. Was it therapeutic, toxic or even lethal to the particular individual that the blood sample was drawn from? Concentrations of opioid drugs are especially difficult to interpret, because of large interindividual differences in innate and acquired tolerance. LÄS MER

  3. 7. Hazardous alcohol use and alcohol use disorders in women : characteristics and vulnerability factors

    Författare :Åsa Magnusson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The overall aim of this thesis was to study vulnerability factors associated with hazardous alcohol consumption during pregnancy and alcohol use disorders among Swedish women. Different risk-factors and characteristics were studied, and examined for their ability to discriminate or identify different subtypes (type I/late onset and type II/early onset) of alcohol dependence (alcoholism). LÄS MER

  4. 8. Interactions between the opioid and serotonin systems in chronic pain : quantitative live cell study by fluorescence cross-correlation spectroscopy (FCCS)

    Författare :Vlad Radoi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chronic pain is a major health issue worldwide. It enacts considerable suffering on the affected individuals and significantly increases the societal burden, as it is the most common reason why individuals seek sick leave and ask for medical help. LÄS MER