Sökning: "OPLS-DA"

Visar resultat 1 - 5 av 12 avhandlingar innehållade ordet OPLS-DA.

  1. 1. Cardiac hypertrophy : transcription patterns, hypertrophic progression and extracellular signalling

    Författare :Nina Gennebäck; Stellan Mörner; Anders Waldenström; Urban Hellman; Ali J Marian; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cardiac hypertrophy; HCM; gene expression; OPLS-DA; multivariate dataanalysis; cardiomyocytes; exosomes; microvesicles; Medicine; medicin;

    Sammanfattning : Background: The aim of this thesis was to study transcription patterns and extracellular signalling of the hypertrophic heart to better understand the mechanisms initiating, controlling and maintaining cardiac hypertrophy.Cardiac hypertrophy is a risk factor for cardiovascular morbidity and mortality. LÄS MER

  3. 2. Stress response in the cyanobacterium Synechocystis sp. PCC 6803

    Författare :Helder Miranda; Christiane Funk; Hans-Erik Åkerlund; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cyanobacteria; High light; heat stress; ROS; Photosynthesis; Photosystem II; Deg HtrA proteases; small CAB-like proteins; Refraction-2D™; MALDI-TOF; 2D-gel; GC-MS; PCA; OPLS-DA; EPS; S-layer; Biochemistry; Biokemi; biokemi; Biochemistry;

    Sammanfattning : Adaptation to environmental changes is important for the survival of living organisms. Under extreme abiotic conditions, organic molecules (such as lipids, proteins and nucleic acids) are prone to damage. LÄS MER

  4. 3. The relationship between fly ash chemistry and the thermal formation of polychlorinated pollutants during waste incineration

    Författare :Duong Ngoc Chau Phan; Stellan Marklund; Bogdan Dlugogorski; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Incinerations; dioxins; PCDD Fs; PCBs; PCNs; flue gas; fly ash; sampling; particle characterization; XPS; XRD; SEM EDX; formation; chlorination; PCA; OPLS; OPLS-DA;

    Sammanfattning : The thermal formation of polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), biphenyls (PCBs), and naphthalenes (PCNs) is a major problem in waste incineration. Ideally, rather than relying on air cleaning systems and treatment techniques, their formation should be minimized or, if possible eliminated. LÄS MER

  5. 4. Proteomics and metabolomics in biological and medical applications

    Författare :Liudmila Shiryaeva; Wolfgang P. Schröder; Pernilla Wikström; Peter Roepstroff; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; 2D-DIGE; biomarkers; cold-acclimation; conifer; freezing tolerance; GC-MS; metabolomics; multiple hypothesis test; multivariate analysis; OPLS-DA; Picea obovata; plasma; prostate cancer; proteomics; ProteoMiner; Siberian spruce;

    Sammanfattning : Biological processes in living organisms consist of a vast number of different molecular networks and interactions, which are complex and often hidden from our understanding. This work is focused on recovery of such details for two quite distant examples: acclimation to extreme freezing tolerance in Siberian spruce (Picea obovata) and detection of proteins associated with prostate cancer. LÄS MER

  7. 5. Epidemiology and statistical modeling in burn injuries

    Författare :Homayoun Sadeghi Bazargani; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Burn injuries;

    Sammanfattning : An important issue in assessing the epidemiology of injuries, including burns, is the investigation of appropriate methodologies and statistical modeling techniques to study injuries in an efficient and trustworthy manner. The overall aim of this thesis is to analyze epidemiological patterns and assess the appropriateness of supervised statistical models to investigate burn risks and patterns. LÄS MER