Sökning: "ODC"
Visar resultat 6 - 10 av 14 avhandlingar innehållade ordet ODC.
6. Structural Studies of Polyamine Biosynthesis Enzymes: Potential Targets for Drugs against Tropical Parasites
Sammanfattning : Two enzymes involved in the biosynthesis of polyamines, ornithine decarboxylase (ODC, from human and Leishmania donovani) and spermidine synthase (SPDS, from Plasmodium falciparum and Caenorhabditis elegans) were studied using biochemical methods, homology modelling and X-ray crystallography. ODC catalyses the first and committed step in polyamine biosynthesis, the decarboxylation of ornithine to putrescine. LÄS MER
7. Project Evaluation in Development Cooperation : A Meta-Evaluative Case Study in Tanzania
Sammanfattning : The research reported here is a meta-evaluative case study of project evaluation in the context of Official Development Cooperation (ODC) in the education sector in Tanzania, where the particular focus is on capturing the relative values attached to evaluation by various stakeholder groups.Perspectives from the constructivist paradigm are adopted, implying relativist ontology, subjectivist epistemology, and naturalistic interpretive methodology. LÄS MER
8. Amyloid precursor protein : cellular studies and animal models
Sammanfattning : Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterised by a number of neuropathological features, including extracellular deposits composed primarily of amyloid-β (Aβ) peptides. Aβ is derived from proteolysis of the amyloid precursor protein (APP) by consecutive action of β and γ-secretases. LÄS MER
9. Adapt, Survive or Die - Metabolic Imbalances and the Enteric Nervous System
Sammanfattning : Abstract: In this thesis the questions “do enteric neurons adapt to survive in conditions of obesity/type 2-diabetes (T2D) related metabolic imbalances? Or do they die?” are asked. Obese and T2D patients have high rates of gastrointestinal (GI) symptoms. LÄS MER
10. Polyamine Pathway as Drug Target against Malaria
Sammanfattning : Malaria, caused by the protozoan parasite Plasmodium falciparum is responsible for about 600.000 death cases every year. Mainly affected are populations of subtropical countries in Africa and the largest groups of victims are children below the age of 5 years. LÄS MER