Sökning: "O6-methylguanineDNAmethyltransferase"

Hittade 1 avhandling innehållade ordet O6-methylguanineDNAmethyltransferase.

1. 1. O6-methylguanine-DNA-methyltransferase and DNA mismatch repair in relation to drug resistance in malignant melanoma

   Författare :Shuhua Ma; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Melanoma; chemotherapy; dacarbazine; drug resistance; O6-methylguanineDNAmethyltransferase; DNA mismatch repair;

   Sammanfattning : Although the survival rate of patients with malignant melanoma has improved, treatment of the disease poses large problems since disseminated melanoma frequently shows primary resistance to chemotherapy. Resistance to chemotherapy is thus a major clinical problem and a cause of failure in the treatment of metastatic malignant melanoma. LÄS MER