Sökning: "O-sulfotransferase"

Hittade 4 avhandlingar innehållade ordet O-sulfotransferase.

  1. 1. In Vitro Studies of the Substrate Specificities of Heparan Sulfate 2-O- and 6-O-sulfotransferases

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Emanuel Smeds; Uppsala universitet.; [2004]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; heparan sulfate; heparin; sulfotransferase; 2-O-sulfotransferase; 6-O-sulfotransferase; polysaccharide biosynthesis; glycosaminoglycan; O-sulfotransferase; proteoglycan; Biokemi; MEDICINE Chemistry Biochemistry; MEDICIN Kemi Biokemi;

    Sammanfattning : Heparan sulfate (HS), a linear negatively charged polysaccharide located at the cell surface and in the extracellular matrix, interacts with, and thereby regulates the functions of numerous proteins. HS-protein interactions depend on the fine structure of HS, especially its sulfation pattern. LÄS MER

  2. 2. Biosynthesis of Dermatan Sulphate. Enzymatic mechanism and role of cytokines

    Detta är en avhandling från Kerstin Tiedemann, Dept of Cell and Molecular Biology, Box 94, 221 00 Lund, Sweden

    Författare :Kerstin Tiedemann; [2000]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dermatan sulphate; 4-O-sulfotransferase; Co-polymeric structure; biglycan; decorin; Biochemistry; Biokemi; C5-epimerase; Metabolism;

    Sammanfattning : Dermatan sulphate is a prominent feature of several different proteoglycans and occurs in almost every tissue of the body. It is an unbranched polymer containing the repeating disaccharide unit of N-acetylgalactosamine and D-glucuronic acid or L-iduronic acid. LÄS MER

  3. 3. Towards cell replacement therapy in Parkinson’s disease. Proteoglycans and Nogo-A as modulators of axonal growth in midbrain dopaminergic neurons

    Detta är en avhandling från Department of Experimental Medical Science, Lund Univeristy

    Författare :Zuzanna Kurowska; [2012]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LUHMES cells; substantia nigra pars compacta; microarray; heparan sulphate 3-O-sulfotransferase; neurocan; midbrain dopaminergic neurons; grafting; embryonic stem cells; proteoglycans; glycosaminoglycans; Nogo-A; cell replacement therapy; Parkinson’s disease;

    Sammanfattning : Parkinson’s disease (PD) is currently the second most common neurodegenerative disorder (after Alzheimer’s disease). PD is diagnosed on its motor symptoms, which include akinesia, bradykinesia, rigidity, postural imbalance and resting tremor. It is well established that the motor symptoms develop due to lack of dopamine in the striatum. LÄS MER

  4. 4. Formation of Iduronic Acid during Chondroitin/Dermatan Sulfate Biosynthesis

    Detta är en avhandling från Lund University: Faculty of Medicine

    Författare :Emil Tykesson; [2016]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GLYCOSAMINOGLYCAN; CHONDROITIN; DERMATAN; EPIMERASE; SULFOTRANSFERASE; GLYCOSAMINOGLYCAN; CHONDROITIN SULFATE; DERMATAN SULFATE; EPIMERASE; SULFOTRANSFERASE;

    Sammanfattning : All animals and some bacteria can synthesize linear polysaccharides with a backbone of repeating disaccharideunits, called glycosaminoglycans (GAGs). The GAGs are either attached to a protein core, as in proteoglycans (PGs), or exist as free polymer chains, as in hyaluronan. LÄS MER