Sökning: "Nude mice"

Visar resultat 6 - 10 av 63 avhandlingar innehållade orden Nude mice.

1. 6. Gene Therapy with Interferon Alpha and the Angiogenic Inhibitor, Vasostatin, in Neuroendocrine Tumors of the Digestive System

   Författare :Minghui Liu; Kjell Oberg; Yinghua Zhou; Bertram Wiedenmann; Uppsala universitet; []
   Nyckelord :Internal medicine; neuroendocrine tumor; interferon-α; vasostatin; vinculin; tumor suppressor gene; nude mice; gene therapy; Invärtesmedicin;

   Sammanfattning : IFN-α has been applied in medical treatment of various neuroendocrine (NE) tumors, either alone or combination with somatostatin analogues. They can improve clinical symptoms in 50-70% of patients but a significant tumor reduction is only observed in 5-15% patients. Vasostatin (vaso) is believed to be an angiogenic inhibitor. LÄS MER

3. 7. Effects of sex steroids and tamoxifen on VEGF in the breast

   Författare :Stina Garvin; Charlotta Dabrosin; Lars Holmgren; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; angiogenesis; breast cancer; estradiol; MCF-7; microdialysis; nude mice; progesterone; sVEGFR-1; VEGFR-2; Oncology; Onkologi;

   Sammanfattning : Sex steroid exposure constitutes a risk factor for breast cancer, but little is known about the effects of sex steroids on factors mediating angiogenesis, the development of new blood vessels, in normal and malignant breast tissue. In this thesis we have investigated the effects of estradiol, progesterone, and the nonsteroidal anti-estrogen tamoxifen on vascular endothelial growth factor (VEGF) and its receptors (VEGFR-1 and VEGFR-2) in normal human breast tissue, endothelial cells, and breast cancer. LÄS MER

4. 8. Effects of sex steroids and tamoxifen on matrix metalloproteinase activity and generation of endostatin in the breast

   Författare :Ulrika W. Nilsson; Charlotta Dabrosin; Lena Claesson-Welsh; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Angiogenesis; Breast cancer; TGF-β1; Endostatin; Estradiol; Mammary gland; Matrix metalloproteinases; MCF-7; Microdialysis; Nude mice; Tamoxifen; Oncology; Onkologi;

   Sammanfattning : Sex steroids are inevitable in women. However, long-term exposure to sex steroids increases the risk of breast cancer. A complete understanding of sex steroid control of the breast and how it relates to breast cancer risk is still lacking. LÄS MER

5. 9. Pharmacokinetic and pharmacodynamic studies on cisplatin in mice and men

   Författare :Anders Johnsson; Bröstcancer-genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cytologi; cancerology; oncology; Cytology; immunohistochemistry; nephrotoxicity; pharmacodynamics; pharmacokinetics; Cisplatin; DNA adducts; platinum; onkologi; cancer; Pharmacological sciences; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

   Sammanfattning : Methodological tools for studies of the cytostatic agen cisplatin (CDDP) were explored and applied to elucidate various aspects of pharmacokinetics, drug distribution, chemomodulation and pharmacodynamics. An immunohistochemical assay for analysis of CDDP-DNA adducts, i.e. LÄS MER

7. 10. Lutetium-177-octreotate treatment of small intestine neuroendocrine tumors - Radiation biology as basis for optimization

   Författare :Johan Spetz; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Peptide receptor radionuclide therapy; PRRT; somatostatin receptors; SSTR; midgut carcinoid; radiogenomics;

   Sammanfattning : Patients with neuroendocrine tumors (NETs) often have metastatic spread at the time of diagnosis. NETs frequently express somatostatin receptors (SSTR) that can be targeted by radiolabeled somatostatin analogs (e.g. 177Lu-octreotate). LÄS MER