Sökning: "Nude mice"

Visar resultat 21 - 25 av 63 avhandlingar innehållade orden Nude mice.

1. 21. Targeted radionuclide therapy for patients with neuroendocrine tumours with focus on normal tissue response in 177-Lu-DOTATATE treatment

   Författare :Johanna Svensson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Radionuclide therapy; Neuroendocrine tumours; 177Lu-DOTATATE; dosimetry; normal tissue response;

   Sammanfattning : Targeted radionuclide therapy with 177Lu-DOTATATE for patients with neuroendocrine tumours utilises the frequent overexpressing of somatostatin receptors on the tumour cells. This treatment modality has demonstrated valuable patient benefits and is well tolerated. However, renal and bone marrow toxicity can become dose limiting and persisting. LÄS MER

3. 22. Expression and function of the protein tyrosine phosphatases SHP-1 and SHP-2 in prostate cancer

   Författare :Helena Tassidis; Institutionen för translationell medicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer SHP-1SHP-2 IL-6phosphorylationsignalling pathways;

   Sammanfattning : Prostate cancer is one of the most frequent cancers in males in Western countries. Radical prostatectomy serves as the first line of treatment for patients with localised prostate cancer. However, in many cases the cancer will recur. It is currently difficult to identify those patients at a high risk of tumour recurrence. LÄS MER

4. 23. The role of suppressor of fused in development and tumorigenesis in the mouse

   Författare :Karin Heby-Henricson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Embryonic development is a process that involves a number of evolutionarily well-conserved signaling cascades, including the hedgehog pathway. Mutations in components of this pathway have been identified in certain developmental disorders, and in many different kinds of cancers. LÄS MER

5. 24. Aspects on Diagnosis and Treatment of Gastrointestinal Neuroendocrine Tumours

   Författare :Christina Swärd; Göteborgs universitet; []
   Nyckelord :Carcinoid; Endocrine pancreatic tumour; Neuroendocrine; Octreotide; Somatostatin receptor; Peptide receptor; Radionuclide therapy; Absorbed dose; Chromogranin A; Liver transplantation;

   Sammanfattning : Aspects on Diagnosis and Treatment of Gastrointestinal Neuroendocrine Tumours Background. Gastroenteropancreatic neuroendocrine tumours (GEP-NETs) originate from endocrine cells of the intestinal mucosa and pancreas. LÄS MER

7. 25. Islet xenograft rejection : studies in the pig-to-rodents and pig-to-primate models

   Författare :Lars Wennberg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Xenotransplantation; islets; rejection; porcine; immunosuppression; C-peptide;

   Sammanfattning : The aims of this thesis was: 1) to compare islet allo- and xenograft rejection in rats, using immunosuppression with CsA in a mixed allogeneic-xenogeneic islet transplantation model, 2) to evaluate the efficacy of various immunosuppressive drugs, with special reference to Leflunomide, in preventing islet xenograft rejection in the pig-to-rat model, 3) to perform an immunohistochemical study of porcine islet xenograft rejection in primates including primates treated with CsA+DSG, and 4) to study the metabolism and excretion of porcine C-peptide in mice, with special reference to the use of donor-specific C-peptide for monitoring islet xenograft function. In summary, the results were as follows: 1. LÄS MER