Sökning: "Nucleotides chemistry"

Visar resultat 1 - 5 av 30 avhandlingar innehållade orden Nucleotides chemistry.

  1. 1. Some Aspects of Nucleic Acids Chemistry

    Författare :Edouard Zamaratski; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Bioorganic chemistry; Bioorganisk kemi; Bioorganic chemistry; Bioorganisk kemi; bioorganisk kemi; Biorganic Chemistry;

    Sammanfattning : This thesis is divided into two parts based on a total of 8 papers: Part 1: Synthesis, physicochemical and biochemical studies of chemically modified oligonucleotides and their duplexes and triplexes. Potency of the chromophore conjugated DNA oligonucleotides as antigene and antisense gene repressors was evaluated. LÄS MER

  3. 2. Stereoelectronic effects in nucleosides and nucleotides

    Författare :Christophe Thibaudeau; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Bioorganic chemistry; Bioorganisk kemi; Bioorganic chemistry; Bioorganisk kemi; bioorganisk kemi; Biorganic Chemistry;

    Sammanfattning : This thesis is based on 12 original publications from 1994-98. Intramolecular stereoelectronicforces (anomeric and gauche effects), beside intermolecular forces such as hydrogen bonding,base stacking, electrostatics and hydration, have been found to be responsible for the localstructural changes of DNA and RNA and their components. LÄS MER

  4. 3. Selective protein functionalisation via enzymatic phosphocholination

    Författare :Philipp Ochtrop; Christian Hedberg; Tom Grossmann; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; chemical biology; organic synthesis; site-selective protein labeling; PTM; phosphocholination; nucleotides; bioorthogonal chemistry; proteomics; IMPDH2;

    Sammanfattning : Proteins are the most abundant biomolecules within a cell and are involved in all biochemical cellular processes ultimately determining cellular function. Therefore, to develop a complete understanding of cellular processes, obtaining knowledge about protein function and interaction at a molecular level is critical. LÄS MER

  5. 4. Modeling DNA Damage

    Författare :Patric Schyman; Aatto Laaksonen; Sason Shaik; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; DNA; Ionizing radiation; DNA radicals; Strand break; Hydrogen abstraction; Density Functional Theory; Car-Parrinello Molecular Dynamics; QM MM; Physical chemistry; Fysikalisk kemi; Physical Chemistry; fysikalisk kemi;

    Sammanfattning : In this thesis methods of computational chemistry have been used to examine DNA damaging processes initiated by ionizing radiation, free radicals, or Low-Energy Electrons (LEE). The computational chemistry method based on quantum mechanics that has been mainly used here is the Density Functional Theory (DFT). LÄS MER

  7. 5. Computational studies of DNA sequencing with graphene nanopores

    Författare :Lijun Liang; Yaoquan Tu; Alexander Lyubartsev; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; DNA sequencing; Graphene nanopore; Molecular dynamic simulation; Kemi; Chemistry;

    Sammanfattning :     The aim of DNA sequencing is to obtain the order of DNA composition comprising the base pairs A (adenine) T (thymine), and C (cytosine) G (guanine). The fast development of DNA sequencing technology allows us to better understand the relationships among diseases, inheritance, and individuality. LÄS MER