Sökning: "Nucleosome positioning"

Visar resultat 6 - 10 av 15 avhandlingar innehållade orden Nucleosome positioning.

  1. 6. Genome-Wide Studies of Transcriptional Regulation in Mammalian Cells

    Författare :Ola Wallerman; Claes Wadelius; Jussi Taipale; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ChIP; ChIP-chip; ChIP-seq; transcription factors; motif discovery; nucleosome positioning; HepG2; genome-wide; RNA-seq; Medical genetics; Medicinsk genetik; Medical Genetics; Medicinsk genetik;

    Sammanfattning : The key to the complexity of higher organisms lies not in the number of protein coding genes they carry, but rather in the intrinsic complexity of the gene regulatory networks. The major effectors of transcriptional regulation are proteins called transcription factors, and in this thesis four papers describing genome-wide studies of seven such factors are presented, together with studies on components of the chromatin and transcriptome. LÄS MER

  3. 7. DNA topoisomerases and nucleosome dynamics in fission yeast

    Författare :Ulrika Norman Axelsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The organization of DNA and associated proteins into chromatin allows for compaction and protection of large eukaryotic genomes. However, it also poses a challenge to fundamental cellular processes such as DNA replication, recombination, repair and transcription. LÄS MER

  4. 8. Studies on nuclear factor 1 binding to nucleosomal DNA

    Författare :Patrik Blomquist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :nuclear factor 1; nucleosome; glucocorticoid receptor; triplex DNA; the SWISNF complex; A-tracts; MMTV LTR;

    Sammanfattning : The organisation of DNA into chromatin will influence on transcriptional regulation. The first event in transcriptional activation is the binding of transcription factors to specific binding sites in the regulatory regions of the gene. LÄS MER

  5. 9. Guardians of the genome : Connecting chromatin structure and genome integrity in Saccharomyces cerevisiae

    Författare :Stefanie Lena Bauer; Stefan U. Åström; Brian Luke; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : Branched DNA structures arise during recombination and during other DNA repair processes such as repair of stalled replication forks. One branched structure, the Holliday Junction (HJ), is a four-way junction that can connect sister chromatids or homologous chromosomes. We show a physical interaction between the HJ-cleaving enzyme Yen1 and Uls1. LÄS MER

  7. 10. Chromatin remodelers and their roles in chromatin organization

    Författare :Annelie Strålfors; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The DNA in the eukaryotic nucleus is organized into a complex DNA-protein structure called chromatin. The basic repeating unit of chromatin is the nucleosome, which consists of 147 bp of DNA wrapped around a histone protein octamer. LÄS MER