Sökning: "Nucleosome positioning"

Visar resultat 1 - 5 av 11 avhandlingar innehållade orden Nucleosome positioning.

  1. 1. Nucleosome positioning : Impact on transcription factors access

    Detta är en avhandling från Stockholm : Karolinska Institutet, false

    Författare :Qiao Li; Karolinska Institutet.; Karolinska Institutet.; [1996]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glucocorticoid receptor; transcription factor; gene regulation; nucleosome; nucleosome positioning; DNA-bending sequence;

    Sammanfattning : Nucleosome Positioning: Impact on Transcription Factors Access Qiao Li Laboratory of Molecular Genetics, Department of Cell and Molecular Biology Medical Nobel Institute, Karolinska Institute, S-171 77 Stockholm, SwedenIn the eukaryotic cell nucleus, DNA is organized into nucleosomes. Some of theregulatory regions are integrated into sequence-specifically positionednucleosomes. LÄS MER

  2. 2. The Functional Significance and Chromatin Organisation of the Imprinting Control Regions of the H19 and Kcnq1 Genes

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Meena Kanduri; Uppsala universitet.; [2004]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular genetics; DNA methylation; Imprinting control region; Chromatin; Insulator; Nucleosome positioning; Genetik; NATURAL SCIENCES Biology Cell and molecular biology Genetics; NATURVETENSKAP Biologi Cell- och molekylärbiologi Genetik;

    Sammanfattning : Genomic imprinting is a phenomenon through which a subset of genes are epigenetically marked during gemtogenisis. This mark is maintained in the soma to often manifest parent of origin-specific monoalleleic expresson patterns. LÄS MER

  3. 3. Decoding the Structural Layer of Transcriptional Regulation Computational Analyses of Chromatin and Chromosomal Aberrations

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Robin Andersson; Uppsala universitet.; [2010]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chromatin; Nucleosome positioning; Histone modifications; Chromosomal aberrations; Transcriptional regulation; Array-CGH; Next generation sequencing; ChIP-chip; NATURAL SCIENCES Biology Other biology Bioinformatics; NATURVETENSKAP Biologi Övrig biologi Bioinformatik; Bioinformatik; Bioinformatics;

    Sammanfattning : Gene activity is regulated at two separate layers. Through structural and chemical properties of DNA – the primary layer of encoding – local signatures may enable, or disable, the binding of proteins or complexes of them with regulatory potential to the DNA. LÄS MER

  4. 4. Genome-Wide Studies of Transcriptional Regulation in Mammalian Cells

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Ola Wallerman; Uppsala universitet.; [2010]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ChIP; ChIP-chip; ChIP-seq; transcription factors; motif discovery; nucleosome positioning; HepG2; genome-wide; RNA-seq; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Clinical genetics Medical genetics; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Klinisk genetik Medicinsk genetik; Medical Genetics; Medicinsk genetik;

    Sammanfattning : The key to the complexity of higher organisms lies not in the number of protein coding genes they carry, but rather in the intrinsic complexity of the gene regulatory networks. The major effectors of transcriptional regulation are proteins called transcription factors, and in this thesis four papers describing genome-wide studies of seven such factors are presented, together with studies on components of the chromatin and transcriptome. LÄS MER

  5. 5. DNA topoisomerases and nucleosome dynamics in fission yeast

    Detta är en avhandling från Stockholm : Karolinska Institutet, Dept of Biosciences and Nutrition

    Författare :Ulrika Norman Axelsson; Karolinska Institutet.; Karolinska Institutet.; [2015]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The organization of DNA and associated proteins into chromatin allows for compaction and protection of large eukaryotic genomes. However, it also poses a challenge to fundamental cellular processes such as DNA replication, recombination, repair and transcription. LÄS MER