Sökning: "Nuclear Proteins analysis"

Visar resultat 1 - 5 av 170 avhandlingar innehållade orden Nuclear Proteins analysis.

  1. 1. Functional studies of nuclear envelope-associated proteins in Saccharomyces cerevisiae

    Författare :Ida Olsson; Ann Mutvei; Valérie Doye; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Nucleus; nuclear envelope; nuclear pore complexes; vesicular traffic; arginine methylation; Rmt2; Cwh43; Myr1; Biochemistry; Biokemi; biokemi; Biochemistry;

    Sammanfattning : Proteins of the nuclear envelope play important roles in a variety of cellular processes e.g. transport of proteins between the nucleus and cytoplasm, co-ordination of nuclear and cytoplasmic events, anchoring of chromatin to the nuclear periphery and regulation of transcription. LÄS MER

  3. 2. The role of nuclear envelope proteins in chromatin organization, differentiation and disease

    Författare :Cecilia Bergqvist; Einar Hallberg; Philippe Collas; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Nuclear envelope proteins; chromatin organization; epigenetics; differentiation; quantitative image analysis; Samp1; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : In eukaryotes the genetic material is separated from the cytoplasm by the nuclear envelope (NE), consisting of the outer and inner nuclear membrane, the nuclear lamina and the nuclear pores. The genetic material is highly structured with transcriptionally inactive heterochromatin enriched at the nuclear periphery and transcriptionally active euchromatin in the nuclear interior. LÄS MER

  4. 3. Digital Image Analysis of Cells : Applications in 2D, 3D and Time

    Författare :Amalka Pinidiyaarachchi; Carolina Wählby; Ewert Bengtsson; Arvid Lundervold; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Digital image analysis; microscopy; fluorescent staining; watershed segmentation; sub-cellular localization; point-like signals; wavelets; cell confluence; cytology; color spaces.; Image analysis; Bildanalys;

    Sammanfattning : Light microscopes are essential research tools in biology and medicine. Cell and tissue staining methods have improved immensely over the years and microscopes are now equipped with digital image acquisition capabilities. The image data produced require development of specialized analysis methods. LÄS MER

  5. 4. The role of nuclear membrane proteins in differentiation and chromatin organization

    Författare :Cecilia Bergqvist; Einar Hallberg; Neus Visa; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; nuclear membrane proteins; chromatin organization; epigenetics; differentiation; stem cells; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : The nuclear envelope, consisting of an outer and an inner nuclear membrane, surrounds the genomic material. The genomic material (chromatin) is highly structured with (transcriptionally inactive) heterochromatin mostly found in the nuclear periphery and (transcriptionally active) euchromatin mostly found in the nuclear interior. LÄS MER

  7. 5. Imaging the molecular pathways of neurodegeneration : New pathologies of SCA7

    Författare :Frida Niss; Anna-Lena Ström; Einar Hallberg; Georg Auberger; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurodegeneration; SCA7; Polyglutamine diseases; RNA binding proteins; Aggregation; Stress granules; Chromatin organization; Quantitative image analysis; Nuclear envelope; Nuclear pore complex; Nucleocytoplasmic transport; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : Spinocerebellar Ataxia type 7 (SCA7) is a genetic neurodegenerative disease with lethal outcome that affects the cerebellum and retina of patients. This thesis focuses on characterising molecular pathological pathways that cause toxicity and cell death in SCA7. LÄS MER