Sökning: "Nuclear Factor kappaB"

Visar resultat 1 - 5 av 23 avhandlingar innehållade orden Nuclear Factor kappaB.

1. 1. Regulation of cytokine-induced nitric oxide production in insulin-producing cells

   Författare :Malin Flodström; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Diabetes; pancreatic islets; insulin-producing cells; cytokines; nitric oxide; inducible nitric oxide synthase; nuclear factor-kappaB; interferon regulatory factor-1; arginine; citrulline; argininosuccinate synthetase; insulin release; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

   Sammanfattning : Cytokine-induced expression of the inducible form of nitric oxide synthase (iNOS) and production of nitric oxide (NO) may contribute to pancreatic β-cell damage during the development of type 1 diabetes. iNOS catalyses the conversion of arginine into citrulline and NO, a reaction regulated by the amount of expressed iNOS enzyme and by the cellular availability of arginine. LÄS MER

3. 2. Cytokine regulation of pancreatic -cell function with special reference to the pathogenesis of type 1 diabetes

   Författare :Johnny Sternesjö; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Diabetes; pancreatic islets; insulin secretion; cytokines; nitric oxide; streptozotocin; NOD mice; proteasome; nuclear factor-kappaB; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

   Sammanfattning : Cytokines produced by inflammatory cells have been implicated in the pathogenesis of type 1 diabetes. The overall aim of the present work was to test how different cytokines, supposed to be present in the insulitic lesion, could influence the function of islets of Langerhans. LÄS MER

4. 3. The nuclear factor k[kappa]B signal transduction pathway : its role in atherogenesis and intimal hyperplasia

   Författare :De-xiu Bu; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Atherosclerosis; intimal hyperplasia; NF-kappaB; NGAL; Telomerase; Leukotriene B4;

   Sammanfattning : Vascular inflammation is a hallmark of major cardiovascular diseases such as atherosclerosis, and also suggested as a critical component implicated in intimal hyperplasia. Given its central role in regulating expression of inflammatory genes, the nuclear factor kappaB (NF-kappaB) signal transduction pathway was postulated to play an important role in these pathological processes. LÄS MER

5. 4. Regulation of human macrophage gene expression by oxidized low density lipoprotein. Studies on tumor necrosis factor-a and global gene expression profiles

   Författare :Mikael C. O. Englund; Göteborgs universitet; []
   Nyckelord :atherosclerosis; macrophage; gene expression; TNF-a; oxidized LDL; oxysterol; transcription factor; microarray;

   Sammanfattning : Atherosclerosis is a multifactorial and progressive disease that is characterized by a focal thickening of the arteries caused by accumulation of lipoproteins, extracellular matrix, and the migration and proliferation of various cell types. Among the cells found in atherosclerotic lesions are macrophages, which accumulate lipids and are transformed into foam cells. LÄS MER

7. 5. NF-kappaB in skin immune homeostasis and cancer development

   Författare :Maria Helena Ulvmar; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The outermost part of the skin, the epidermis, is built up by cells called keratinocytes. The epidermis provides a vital barrier between the body and the outer world. It is also a target for constant physical and microbial injury. LÄS MER