Sökning: "Npm1"

Visar resultat 11 - 15 av 16 avhandlingar innehållade ordet Npm1.

  1. 11. Prognostic and biological implications of epigenetic changes in leukemia

    Författare :Stefan Deneberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The field of epigenetic research in hematology and oncology is rapidly expanding. Even so, reliable data linking epigenetic changes to clinical outcomes are scarce. We conducted two retrospective studies in AML. LÄS MER

  3. 12. Human adenovirus – host cell interplay : The role of the cellular zinc finger proteins and mitochondrial DNA

    Författare :Kwangchol Mun; Tanel Punga; Stefan Schwartz; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Adenovirus; Protein VII; Ubiquitination; Chromatin remodeling; Mitochondria;

    Sammanfattning : Human adenovirus (HAdV) is an abundant DNA virus with significant clinical relevance since it cauces a variety of respiratory, ocular, and gastrointestinal diseases. It is also intensively used as a therapeutic tool to treat cancers and to boost immune responses. LÄS MER

  4. 13. Aberrant DNA methylation in acute myeloid leukemia

    Författare :Ying Qu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : DNA methylation is an important epigenetic mechanism that influences development and cancer by regulating gene transcription. Aberrant DNA methylation is a feature of cancer including acute myeloid leukemia (AML). LÄS MER

  5. 14. Identification and characterization of candidate therapeutic targets in acute myeloid leukemia

    Författare :Mia Eriksson; Avdelningen för klinisk genetik; []
    Nyckelord :;

    Sammanfattning : Acute myeloid leukemia (AML) is a fatal disease that is characterized by a rapid expansion of myeloid leukemic blasts with impaired differentiation that accumulate in the bone marrow. The prognosis for AML is generally poor, with a five-year overall survival of around 20% in patients over 60 years old. LÄS MER

  7. 15. Improved statistical methodology for high-throughput omics data analysis

    Författare :Wenjiang Deng; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Over the last two decades, the advent of high-throughput omics technology has substantially revolutionized biological and biomedical research. A large volume of omics data has been produced with the rapid development of sequencing techniques. LÄS MER