Sökning: "Nonlinear Mixed Effects Models"

Visar resultat 1 - 5 av 31 avhandlingar innehållade orden Nonlinear Mixed Effects Models.

  1. 1. Contributions to nonlinear mixed-effects modeling

    Författare :Jacob Leander; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; nonlinear mixed-effects models; stochastic differential equations; parameter estimation; extended Kalman filter; sensitivity equations; stochastic differential equations;

    Sammanfattning : The topic of this thesis is nonlinear mixed-effects models. A nonlinear mixed-effects model is a hierarchical regression model used to analyze measurements from several individuals simultaneously, which allows sharing of information between similar individuals. LÄS MER

  3. 2. Practical Optimal Experimental Design in Drug Development and Drug Treatment using Nonlinear Mixed Effects Models

    Författare :Joakim Nyberg; Andrew C. Hooker; Mats O. Karlsson; Sergei Leonov; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometrics; optimal design; nonlinear mixed effects models; robust design; optimizing drug development; population models; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Sammanfattning : The cost of releasing a new drug on the market has increased rapidly in the last decade. The reasons for this increase vary with the drug, but the need to make correct decisions earlier in the drug development process and to maximize the information gained throughout the process is evident. LÄS MER

  4. 3. Nonlinear Mixed Effects Modeling of Combination Therapies in Oncology

    Författare :Marcus Baaz; Stiftelsen Fraunhofer-Chalmers Centrum för Industrimatematik (FCC); []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacol- ogy; Radiation Therapy; Oncology; Mathematical Modeling; Combination Therapy; Nonlinear Mixed Effects;

    Sammanfattning : It has been shown that simultaneous administration of two or more anticancer agents can have a beneficial effect on cancer patients. This type of treatment is called combination therapy and is nowadays commonly used in the fight against cancer. LÄS MER

  5. 4. Covariate Model Building in Nonlinear Mixed Effects Models

    Författare :Jakob Ribbing; E. Niclas Johnsson; Mats O. Karlsson; Janet Wade; Uppsala universitet; []
    Nyckelord :Pharmacokinetics Pharmacotherapy; Pharmacokinetics; Pharmacodynamics; Modeling; Covariate selection; Stepwise selection; Covariate analysis; Methodology; Model validation; Model evaluation; Type-2 diabetes; Beta-cell function; Meta analysis; Cross-validation; Least absolute shrinkage and selection operator; Pharmacometrics; ED optimization; Farmakokinetik Farmakoterapi;

    Sammanfattning : Population pharmacokinetic-pharmacodynamic (PK-PD) models can be fitted using nonlinear mixed effects modelling (NONMEM). This is an efficient way of learning about drugs and diseases from data collected in clinical trials. LÄS MER

  7. 5. Statistical modeling and design in forestry : The case of single tree models

    Författare :Leakemariam Berhe; Göran Arnoldsson; Göran Broström; Dieter Rasch; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Forest data; Covariance structures; Nonlinear mixed effects models; Tree taper models; Ds-optimal design; Replication-free design.; Statistics; Statistik;

    Sammanfattning : Forest quantification methods have evolved from a simple graphical approach to complex regression models with stochastic structural components. Currently, mixed effects models methodology is receiving attention in the forestry literature. LÄS MER