Sökning: "Non-steroidal Anti-Inflammatory Drugs"
Visar resultat 1 - 5 av 41 avhandlingar innehållade orden Non-steroidal Anti-Inflammatory Drugs.
1. Non-Steroidal Anti-Inflammatory Drugs in Cyclooxygenases 1 and 2 : Binding modes and mechanisms from computational methods and free energy calculations
Sammanfattning : Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly used classes of drugs. They target the cyclooxygenases (COX) 1 and 2 to reduce the physiological responses of pain, fever, and inflammation. Due to their role in inducing angiogenesis, COX proteins have also been identified as targets in cancer therapies. LÄS MER
2. Heterotopic Ossification : Clinical and Experimental Studies on Risk Factors, Etiology and Inhibition by Non-steroidal Anti-inflammatory Drugs
Sammanfattning : In this thesis, occurrence of heterotopic ossification (HO) following total hip arthroplasty (THA) was studied. Preventive effects and complications with non-steroidal anti-inflammatory drugs (NSAIDs) were analyzed. Experimental investigations on bone formation were employed to gain insight to the mechanism of NSAIDs action on bone.(I). LÄS MER
3. Fatty acid amide hydrolase - A target for anti-inflammatory therapies?
Sammanfattning : Anti-inflammatory drugs are a widely used class of therapeutic agents, but the use of non-steroidal anti-inflammatory drugs (NSAID) is hampered by their gastrointestinal side-effects. Recent reports that cyclooxygenase-2 inhibitors may cause cardiovascular events underline the importance of identifying new therapeutic strategies for the treatment of inflammation. LÄS MER
4. Effects of anti-inflammatory drugs on human skeletal muscle adaptations to resistance training
Sammanfattning : Previous studies in young adults suggest that non-steroidal anti-inflammatory drugs (NSAIDs) may impair early skeletal muscle responses to exercise. Whether chronic use of NSAIDs affects skeletal muscle adaptations to resistance training in young adults remains uncertain. LÄS MER
5. A Drosophila Disease-Model for Transthyretin-associated Amyloidosis
Sammanfattning : Amyloidoses comprise a group of gain-of-toxic function protein misfolding diseases, in which normally soluble proteins in their functional state undergo conformational changes into highly organized and generally intractable thread-like aggregates, termed amyloid fibrils. These structures accumulate predominantly in the extracellular space but growing evidence suggests that amyloids may start to form intracellularly. LÄS MER