Sökning: "Non-motor"

Visar resultat 1 - 5 av 35 avhandlingar innehållade ordet Non-motor.

  1. 1. Non-motor symptoms in Parkinson’s disease : modeling and mechanisms

    Författare :Débora Masini; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Parkinson’s disease (PD) is a common neurodegenerative disorder, typically characterized by the progressive death of midbrain dopaminergic neurons projecting from the substantia nigra to other areas within the basal ganglia. Historically, PD has been diagnosed as a purely motor disorder dominated by bradykinesia (slowness of movement), rigidity, resting tremor, and postural instability. LÄS MER

  3. 2. Mechanisms of motor and non-motor complications in experimental parkinsonism

    Författare :Carina Plewnia; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Parkinson’s disease (PD), one of the most common neurodegenerative disorders, is classically characterized by the progressive loss of midbrain dopaminergic neurons and by the emergence of cardinal motor symptoms including rigidity, tremor and bradykinesia. PD treatment relies on pharmacological dopamine replacement, which is the most effective therapy to alleviate motor symptoms. LÄS MER

  4. 3. Daytime sleepiness in Parkinson's disease in relation to other symptoms, disease progression and daily life

    Författare :Arja Vehkala Höglund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The aim of this doctoral thesis is to explore daytime sleepiness (DS) in Parkinson’s disease (PD). The Papers will evaluate how DS is connected to both motor and non-motor symptoms in PD, changes in DS over time, and the consequences of DS for the daily life of people with PD. LÄS MER

  5. 4. New perspectives on pathology in Huntington's disease - characterization of hypothalamic changes

    Författare :Sanaz Gabery; Translationell neuroendokrinologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Huntington’s disease; huntingtin; hypothalamus; oxytocin; vasopressin; orexin; CART; neuroendocrinology; MRI; 3 Tesla; volymetric analysis;

    Sammanfattning : Huntington’s disease (HD) is a neurodegenerative disorder caused by an expansion of the CAG repeat in the huntingtin gene. Non-motor symptoms and signs such as psychiatric disturbances and metabolic dysfunction are also part of the disease manifestation. These symptoms often precede the motor symptoms by decades. LÄS MER

  7. 5. Psychiatric and metabolic disturbances in experimental models of Huntington’s disease

    Författare :Sofia Hult Lundh; Translationell neuroendokrinologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Huntington’s disease; huntingtin; hypothalamus; depression; anxiety; metabolism; neuroendocrinology; mouse models; BACHD; rAAV vectors; leptin;

    Sammanfattning : Non-motor symptoms and signs such as metabolic and psychiatric disturbances have been reported to occur early in Huntington’s disease (HD), a fatal neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin gene. However, there is a lack of understanding of the underlying neurobiological mechanisms responsible for the early non-motor features. LÄS MER