Sökning: "Non insulin dependent diabetes"

Visar resultat 21 - 25 av 77 avhandlingar innehållade orden Non insulin dependent diabetes.

  1. 21. Fatty acids induce potentially atherogenic changes in extracellular matrix proteoglycans

    Författare :Mariam Rodríguez-Lee; Göteborgs universitet; []
    Nyckelord :proteoglycans; glycosaminoglycans; fatty acids; smooth muscle cells; hepatocytes; LDL binding; remnant clearance; insulin resistance; type 2 diabetes;

    Sammanfattning : Insulin resistance and type 2 diabetes (T2D) are associated with an increased prevalence of atherosclerotic cardiovascular disease (CVD). A key step in the initiation of atherogenesis is retention of low density lipoproteins (LDL) in the intima by chondroitin sulfate (CS)-rich proteoglycans (PG). LÄS MER

  3. 22. Mechanisms of impaired insulin release in type-2 diabetes : studies in the GK rat model

    Författare :Amel Guenifi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Goto-Kakizaki GK rat; Type-2 diabetes; insulin secretion; morphometry; adenylyl cyclase AC ; phospholipase-C PLC ; ß-cell;

    Sammanfattning : Type-2 diabetes is a complex syndrome with a polygenic and multifactorial aetiology. It is characterised by its relatively late appearance in life and its mild progressive course. Glucose intolerance can generally be ascribed to disturbed pancreatic hormonal secretion and/or insulin resistance in the liver and extrahepatic tissues. LÄS MER

  4. 23. B cell deviations and type 1 diabetes in the NOD mouse

    Författare :Mia Sundström; Kristina Lejon; Susanna Cardell; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Type 1 diabetes; Autoimmunity; NOD mouse; Idd; TACI; Immune response; Immune complex; immunologi; Immunology;

    Sammanfattning : Type 1 diabetes (T1D) is a chronic autoimmune disease in which the insulin producing β-cells in the pancreatic islets of Langerhans are selectively attacked by the immune system. The β-cells are destroyed resulting in a reduced or eliminated insulin production, which in turn lead to a high blood glucose level. LÄS MER

  5. 24. Non-invasive assessment of dynamic properties in human arteries : with special reference to gestation and diabetes

    Författare :Jie Hu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Acetylcholine; Adolescents; Aorta; Diameter waveforms; Diameter pulse waves; Echo tracking system; Fetal behavioural state; Fetal breathing movements; Gestational diabetes mellitus; Impending birth; Insulin-dependent diabetes mellitus; Laser Doppler; Microcirculation; Pregnancy; Pulse wave velocity; Vascular endothelium; Vascular stiffness; Ultrasound;

    Sammanfattning : Background: The important role played by the intrinsic properties of central arteries in cardiovascular physiology and pathology has been increasingly recognised. Several circulatory disorders are associated with increased arterial stiffness. LÄS MER

  7. 25. Islet amyloid polypeptide : Perspectives on the storage and plasma concentration of islet amyloid polypeptide (IAPP) in rodent models of obesity and non-insulin-dependent diabetes mellitus and aspects of amyloidogenesis andelimination of IAPP

    Författare :Arnold Leckström; Sture Falkmer; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : The present study was aimed to investigate plasma concentrations and pancreatic storage of IAPP in relation to that of insulin in four different animal models with hyperglycemia, hyperinsulinemia, obesity and/or NIDDM. The NMRI mice fed a high-fat diet for six months, the Psammomys on high-energy (HE) diet and the genetically obese (ob/ob) mice studied for one year all revealed significantly elevated plasma IAPP concentrations, while the IAPP levels were unchanged in the spontaneously diabetic GK rats during a glucose tolerance test. LÄS MER