Sökning: "Niels-bjarne Woods"

Hittade 1 avhandling innehållade orden Niels-bjarne Woods.

  1. 1. Development of Gene Therapy for Hematopoietic Stem Cells using Lentiviral Vectors

    Detta är en avhandling från Margareta Ingloff (Secretary) Dept. of Molecular Medicine & Gene Therapy, BMC A12, SE-22184 Lund, Sweden, tel. +46 46 222-0575

    Författare :Niels-Bjarne Woods; [2002]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; embryonic stem cell; Hematopoietic stem cell; lentiviral vector; transduction efficiency; transgene expression; multiple vector copy integration; insertional mutagenesis; NOD SCID mouse; cytogenetics; Genetics; extracellulära vätskor; extracellular fluids; cytogenetik; Genetik; Haematology; Hematologi;

    Sammanfattning : Hematopoietic stem cells are an ideal target for genetic manipulation for the purpose of curing hematological disorders as they have the ability to develop into all blood lineages and to self-renew. In this study we demonstrate that lentiviral vectors, based on HIV-1, can efficiently transfer genes into human hematopoietic progenitor and stem cells as assessed following stem cell transplantation in immune compromised mice. LÄS MER