Sökning: "Next generation sequencing"
Visar resultat 16 - 20 av 180 avhandlingar innehållade orden Next generation sequencing.
16. Extracting Genomic Variations using Selector Technology
Sammanfattning : This thesis describes the development and use of a new class of molecular tools called Selector probes, and its potential for investigations of genetic variation. The Selector technology provides multiplex amplification of targeted DNA sequences with a high specificity, and an enrichment factor in the same order of magnitude as PCR. LÄS MER
17. Facilitating precision medicine through analysis of next-generation sequencing projects
Sammanfattning : Precision medicine constitutes an emerging strategy that aims at the individualization of healthcare by considering the personal molecular features and environmental factors of the patient in question. Genetic biomarkers constitute one dimension of a patient’s molecular phenotype that can allow for treatment stratification. LÄS MER
18. Next generation sequencing to find genetic risk factors in familial cancer
Sammanfattning : In 2015, Cancer is the second leading cause of death worldwide. Genetic predisposition in familial cancer cases is largely unexplained. At the same time, rapid development in sequencing technology results in an unprecedented increase in the amount of whole exome- and whole genome sequencing data. LÄS MER
19. Prognostic and Predictive Somatic Mutations in Colorectal Cancer
Sammanfattning : Colorectal cancer (CRC) is the third most incident and the second deadliest cancer worldwide. Even though CRC incidence is strongly correlated with age, it has been increasing in developing countries and younger individuals. LÄS MER
20. Impact of Drinking Water Treatment and Pipe Biofilms on Bacterial Dynamics in the Distribution System
Sammanfattning : This thesis addresses drinking water quality and microbiology in full-scale drinking water distribution systems (DWDSs). It examines how UV irradiation and slow sand filters (SSFs) alter the water bacteriome, and how the biofilm in the DWDS affects the drinking water quality. LÄS MER